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Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust.
Medicina (Kaunas)
January 2025
Laboratory for Infection Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea.
: Persistent exposure to airborne fine dust (FD) particles contributing to air pollution has been linked to various human health issues, including respiratory inflammation, allergies, and skin diseases. We aimed to identify potential seaweed anti-inflammatory bioactive reagents and determine their effects on systemic inflammatory responses induced by FD particles. : While exploring anti-inflammatory bioactive reagents, we purified compounds with potential anti-inflammatory effects from the seaweed extracts of , , and .
View Article and Find Full Text PDFIron Drives Eosinophil Differentiation in Allergic Airway Inflammation Through Mitochondrial Metabolic Adaptation.
Adv Healthc Mater
January 2025
Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
Eosinophils play a crucial role as effector cells in asthma pathogenesis, with their differentiation being tightly regulated by metabolic mechanisms. While the involvement of iron in various cellular processes is well known, its specific role in eosinophil differentiation has largely remained unexplored. This study demonstrates that iron levels are increased during the differentiation process from eosinophil progenitors to mature and activated eosinophils in the context of allergic airway inflammation.
View Article and Find Full Text PDFMouse pulmonary response following solid surface composite dust inhalation.
Inhal Toxicol
January 2025
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
: Pulmonary exposure to emissions from manipulating solid surface composite (SSC) materials has been associated with adverse health effects in humans and laboratory animals. Previous and investigations of SSC toxicity have been limited by particle delivery methods that do not fully recapitulate the workplace environment. This study sought to determine the acute SSC-induced pulmonary responses whole-body inhalation exposure.
View Article and Find Full Text PDFEnd tuberculosis strategy also requires initiation and integration of a national silicosis control program with the ongoing tuberculosis elimination activities: A review of the silicotuberculosis situation in India.
J Biol Methods
October 2024
Indian Council of Medical Research-National Institute of Occupational Health, Ahmedabad, Gujarat 380016, India.
Background: Earlier studies conducted by Indian researchers have demonstrated that the elimination of tuberculosis (TB) requires proactive control of silicosis, given India's significant burden of silicosis and its common comorbidity, pulmonary TB, also known as silicotuberculosis. The TB Control Indian Health Authority saw human immunodeficiency virus infection, diabetes, and malnutrition, among others, as important risk factors for case findings, but overlooked the significance of silicosis. Silicotuberculosis control is often confronted with challenges of detecting microorganisms, uncertain treatment outcomes, a higher likelihood of mono-drug and multi-drug resistance, and increased mortality due to treatment failure.
View Article and Find Full Text PDFTransboundary hydropolitical conflicts and their impact on river morphology and environmental degradation in the Hirmand Basin, West Asia.
Sci Rep
January 2025
Department of Water Engineering and Management, Tarbiat Modares University, Tehran, Iran.
The Hirmand Transboundary River Basin (HTRB), shared by Afghanistan, Iran, and Pakistan, is a hydrologically critical and politically sensitive region. This basin sustains livelihoods, ecosystems, and agriculture in a region plagued by climatic variability and geopolitical tensions. The Hirmand River, which forms the heart of this basin, faces severe morphological and discharge changes due to upstream water management, climatic shifts, and land use changes, directly impacting downstream ecosystems and human populations.
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