Human herpesvirus 6 (HHV6) antibody was detected by the anticomplement immunofluorescence test in 65 of 592 serum samples (10.9%) obtained from Amerindians belonging to 4 remote communities inhabiting the Amazon Region of Brazil. Seropositivity rates ranged from 5.4% in the Oyampí to 14.9% in the Tucano. Among the Mekranoiti and Tiriyo, the seroprevalence rates were 12.5% and 11.8%, respectively. In children aged 0-10 years, the prevalences of HHV6 antibody ranged from 5.2% to 24.2%, among the Oyampí and Mekranoiti tribes, respectively. In the 11-20 and > 20 years old age groups, percentages of positivity ranged, in the former group, from 9.5% to 17.5% in the Oyampí and Tucano, respectively and, in the latter group, from 1.3% in the Oyampí to 14.8% in the Tucano. The prevalences of HHV6 antibody decreased regularly through the first 3 age-groups in the Mekranoiti and Tiriyo. In addition, frequencies of seropositivity were consistently higher in males than in females in the Mekranoiti (P < 0.05), Oyampí and Tiriyo tribes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0035-9203(94)90280-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis.
J Neurol
December 2024
Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Background And Objectives: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).
Methods: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.
Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer.
Sci Rep
November 2024
Third Department of Breast Surgery, Peking University Cancer Hospital Yunnan Hospital, The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Hospital, Kunming, 650118, China.
Background: There may be potential associations between various pathogens, antibody immune responses, and breast cancer (BC), but the specific mechanisms and causal relationships remain unclear.
Methods: First, multiple Mendelian randomization (MR) methods were used for univariable MR analysis to explore potential causal relationships between 34 antibody immune responses (related to 12 pathogens), 46 antibody immune responses (related to 13 pathogens), antibody responses post-COVID-19 vaccination, 731 immune cell types, and various BC subtypes (including overall BC, ER-positive, ER-negative, Luminal A, Luminal B, Luminal B HER2-negative, HER2-positive, and triple-negative BC). The primary results were then subjected to reverse MR analysis, heterogeneity testing using Cochran's Q, and horizontal pleiotropy testing.
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms.
J Adv Res
November 2024
Immunosciences Lab, Inc., Los Angeles, CA 90035, USA; Cyrex Laboratories, LLC, Phoenix, AZ 85034, USA.
Article Synopsis
- Long COVID is linked to autoimmune responses that affect neural proteins, contributing to conditions like fatigue and mood disorders.
- In a study, researchers measured various immunoglobulin antibodies in Long COVID patients versus healthy controls, finding significant increases in specific antibodies associated with neuronal proteins.
- The findings suggest brain-targeted autoimmunity plays a key role in Long COVID, influencing both physical and psychological symptoms, with certain antibodies serving as strong predictors for the condition's severity.
Human Herpesvirus-6B Infection and Alterations of Gut Microbiome in Patients with Fibromyalgia: A Pilot Study.
Biomolecules
October 2024
The Institute of Microbiology and Virology of the Riga Stradiņš University Science Hub, LV-1067 Riga, Latvia.
Article Synopsis
- * The study included 17 FM patients and 24 healthy individuals, aiming to identify potential biomarkers, detecting human herpesvirus (HHV)-6A and B in patient samples, and measuring related antibodies and cytokine levels.
- * Findings indicated higher detection of HHV-6B in FM patients, particularly those with a BMI of 30 or more, along with significant differences in gut microbiome diversity between FM patients and healthy controls.
Elucidating the causal nexus between antibody-mediated immunity and autoimmune diseases: Insights from bidirectional mendelian randomization, gene expression profiling, and drug sensitivity analysis.
Int Immunopharmacol
December 2024
Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China. Electronic address:
Article Synopsis
- - The study examined how antibodies are causally linked to autoimmune diseases using Mendelian randomization, analyzing data from genome-wide association studies.
- - Results indicated that antibodies triggered by different infections can either increase or decrease the risk of various autoimmune diseases, emphasizing the complex interactions at play.
- - The research identified potential drug and gene targets for treating ankylosing spondylitis, with the AIF1 gene being highlighted as a particularly promising candidate.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!