AI Article Synopsis
- The study examines the potential role of genetic factors, specifically focusing on TNF-alpha, in the development of ankylosing spondylitis (AS) alongside the known HLA-B27.
- A specialized PCR method was used to analyze a specific polymorphism in the TNF-alpha gene (-308 position) in both AS patients and healthy individuals.
- Results showed no significant differences in TNF-alpha allele frequencies between AS patients and healthy controls, suggesting that this genetic variant may not play a major role in AS.
Article Abstract
In addition to HLA-B27, other genetic factors are thought to be involved in the pathogenesis of ankylosing spondylitis (AS). Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base polymorphism located at position -308 of the TNF-alpha gene. An allele-specific polymerase chain reaction was developed to monitor this polymorphism. The frequency of the TNF-alpha alleles was determined in 66 AS patients and 37 healthy controls. The TNF-alpha allele frequency was not significantly different between AS patients and controls.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534773 | PMC |
| http://dx.doi.org/10.1111/j.1365-2249.1994.tb06577.x | DOI Listing |
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