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Metal-halide perovskites (MHPs) have gained substantial interest in the energy and optoelectronics field. MHPs in nanostructure forms, such as nanocrystals and nanowires (NWs), have further expanded the horizons for perovskite nanodevices in geometry and properties. A partial anion exchange within the nanostructure, creating axial heterojunctions, has significantly augmented the potential applications.
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View Article and Find Full Text PDFArtesunate alleviates radiation-induced submandibular gland epithelial cell damage in rats by reducing inflammation and apoptosis.
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View Article and Find Full Text PDFQuercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks.
Biochem Biophys Res Commun
December 2024
Graduate School of Science and Technology, Gunma University, Kiryu, 376-8515, Japan; Graduate School of Nanobioscience, Yokohama City University, Yokohama, 236-0027, Japan; Gunma University Center for Food and Science and Wellness, Gunma University, Kiryu, 376-8515, Japan. Electronic address:
Article Synopsis
- Quercetin, a flavonoid with antioxidant properties, can induce DNA double-strand breaks (DSBs) in a concentration-dependent manner, but the exact mechanism behind this effect is still unclear.
- The study used HeLa cells and gene-knockout cell lines to investigate that quercetin does not primarily involve DNA topoisomerase II (Top2) in inducing DSBs; instead, a transient accumulation of reactive oxygen species (ROS) is linked to this process.
- The DSBs caused by quercetin are mainly repaired through non-homologous end-joining and homologous recombination, suggesting it could be used as a radiomimetic agent with effects similar to X-ray exposure.
Visualization of Biomolecular Radiation Damage at the Single-Particle Level Using Lanthanide-Sensitized DNA Origami.
Nano Lett
September 2024
New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350002, China.
Precise monitoring of biomolecular radiation damage is crucial for understanding X-ray-induced cell injury and improving the accuracy of clinical radiotherapy. We present the design and performance of lanthanide-DNA-origami nanodosimeters for directly visualizing radiation damage at the single-particle level. Lanthanide ions (Tb or Eu) coordinated with DNA origami nanosensors enhance the sensitivity of X-ray irradiation.
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