This study examined the control of cardiovascular dynamics in response to exercise during the development of obesity in dogs. Left atrial pressure (LAP), mean arterial pressure, and cardiac output (CO) were determined both at rest and in response to treadmill exercise (5.6 km/h, 10% grade) first during a control, lean state and then, once a week while the dogs were maintained on a high fat diet (HFD) for 4 weeks. Body weight increased from 22.8 +/- 1.1 to 33.1 +/- 2.0 kg after 4 weeks of HFD. The dogs developed mild hypertension with increases in resting CO, heart rate, and LAP. The response to exercise was characterized by a decrease in LAP when the dogs were lean and, in contrast, by a dramatic increase in LAP during the development of obesity. In addition, after the third week, the dogs could no longer maintain exercise at the original level. These results suggest that abnormal left ventricular function may occur very early during the development of canine obesity.
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