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New preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry.
Vet Q
December 2024
Centre for Encephalopathies and Emerging Transmissible Diseases, Faculty of Veterinary Sciences, University of Zaragoza - Agri-Food Institute of Aragon (IA2), Zaragoza, Spain.
Current diagnostic methods for prion diseases only work in late stages of the disease when neurodegeneration is irreversible. Therefore, biomarkers that can detect the disease before the onset of clinical symptoms are necessary. High-throughput discovery proteomics is of great interest in the search for such molecules.
View Article and Find Full Text PDFassessment of neuroinflammatory cytokines in different stages of ovine natural prion disease.
Front Vet Sci
October 2024
Research Centre for Encephalopathies and Transmissible Emerging Diseases. Institute for Health Research Aragón (IIS) - WOAH Reference Laboratory for BSE and Scrapie, University of Zaragoza, Zaragoza, Spain.
Introduction: According to the neuroinflammatory hypothesis, a cytokine-mediated host innate immune response may be involved in the mechanisms that contribute to the process of neurodegeneration. Specifically, regarding prion diseases, some experimental murine models have evidenced an altered profile of inflammatory intermediaries. However, the local inflammatory response has rarely been assessed, and never in tissues from different natural models throughout the progression of neurodegeneration.
View Article and Find Full Text PDFCryo-EM structure of a natural prion: chronic wasting disease fibrils from deer.
Acta Neuropathol
October 2024
Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation and also for human and livestock health. The structures of infectious prions that cause CWD and other natural prion diseases of mammalian hosts have been poorly understood. Here we report a 2.
View Article and Find Full Text PDFBackground: The most common natural prion disease that primarily affects sheep and goats is scrapie. It belongs to a group of disorders known as transmissible spongiform encephalopathies, which impact both humans and animals.
Aim: The research is aimed to examine and confirm the presence of scrapie in Libya using immunohistochemistry (IHC) techniques.
Transmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution.
Vet Res
July 2024
Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Sandnes, Norway.
Chronic wasting disease (CWD), a prion disease affecting cervids, has been known in North America (NA) since the 1960s and emerged in Norway in 2016. Surveillance and studies have revealed that there are different forms of CWD in Fennoscandia: contagious CWD in Norwegian reindeer and sporadic CWD in moose and red deer. Experimental studies have demonstrated that NA CWD prions can infect various species, but thus far, there have been no reports of natural transmission to non-cervid species.
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