Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956512 | PMC |
Publication Analysis
Top Keywords
Similar Publications
pH-sensitive polyglycerol nanogels for periodontitis treatment through antibacterial and pro-angiogenesis action.
Angew Chem Int Ed Engl
January 2025
Freie Universität Berlin Fachbereich Biologie Chemie Pharmazie: Freie Universitat Berlin Fachbereich Biologie Chemie Pharmazie, Department of Biology, Chemistry, Pharmcy, Takustr. 3, 14195, Berlin, GERMANY.
Periodontitis is a microbe-driven inflammatory disease leading to bone resorption and tissue destruction. We propose a dual-functional nanogel complex armed with the antimicrobial drug triclosan (TCS) and the pro-angiogenesis medication deferoxamine (DFO) for combating microbial pathogens and promoting tissue regeneration. The nanogel system (NG-TCS-DFO) that we fabricated from linear polyglycerol exhibits well-defined spherical morphology and a positively charged surface for bacteria adhesion.
View Article and Find Full Text PDFVariable surface antigen expression, virulence, and persistent infection by malaria parasites.
Microbiol Mol Biol Rev
January 2025
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
SUMMARYThe human malaria parasite is known for its ability to maintain lengthy infections that can extend for over a year. This property is derived from the parasite's capacity to continuously alter the antigens expressed on the surface of the infected red blood cell, thereby avoiding antibody recognition and immune destruction. The primary target of the immune system is an antigen called PfEMP1 that serves as a cell surface receptor and enables infected cells to adhere to the vascular endothelium and thus avoid filtration by the spleen.
View Article and Find Full Text PDFHow I use noninvasive prenatal testing for red blood cell and platelet antigens.
Blood
December 2024
Sanquin, Amsterdam, Netherlands.
Alloimmunization during pregnancy occurs when a mother produces antibodies against fetal antigens, leading to complications like hemolytic disease of the fetus and newborn (HDFN) and fetal and neonatal alloimmune thrombocytopenia (FNAIT). HDFN involves destruction of fetal red blood cells, potentially causing severe anemia, hydrops fetalis, and fetal death. FNAIT affects fetal platelets and possibly endothelial cells, resulting in risk of intracranial hemorrhage and brain damage.
View Article and Find Full Text PDFAs one of the most destructive and invasive cancers, pancreatic cancer exhibits complex tumor heterogeneity, which has been a major challenge for clinicians in terms of patient treatment and prognosis. The toll-like receptor (TLR) pathway is closely related to the immune microenvironment within various cancer tissues. To explore the development pattern of pancreatic cancer and find an ideal biomarker, our research has explored the mechanism of the TLR pathway in pancreatic cancer.
View Article and Find Full Text PDFInflammation and mechanical force-induced bone remodeling.
Periodontol 2000
December 2024
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Periodontitis results from an imbalance between host immune responses and microbial interactions, leading to inflammation and loss of bone structure.
- The transition from gingivitis to periodontitis may be influenced by inflammation's proximity to bone, affecting bone resorption and formation.
- Recent research using single-cell RNA sequencing has revealed the distinct roles of various cell types in inflammation and bone remodeling, highlighting the complex interactions in conditions like periodontitis and orthodontic movement.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!