The authors review the published data on antibodies to endothelial cells observed in patients suffering from diffuse connective tissue diseases. In these patients the histologic lesions are found in vessels of different sizes and localizations. It is believed that such auto-antibodies may have a role in the pathogenesis and prognosis of these disorders. The preliminary results of a study of the antigenicity of endothelial cells in mixed connective tissue disease are also presented.
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