1. Immature mice were induced to ovulate by pregnant serum gonadotropin and human chorionic gonadotropin. 2. The ribosome inactivating proteins luffaculin, luffin-a, luffin-b and momorcochin were administered i.p. 3. It was found that all four ribosome inactivating proteins elicited a reduction in the circulating titer of estradiol-17 beta. 4. Both luffaculin and momorcochin brought about an increase in the number of degenerated oocytes. 5. Only momorcochin caused a decrease in the ovarian weight and the number of ovulated oocytes.
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