[An evaluation of the prognostic significance of the structure of the chromosomal translocation t (9; 22) locus in chronic myeloleukemia].

The site of the break of chromosome 22 was investigated by blot hybridization and polymerase chain reaction in 41 patients with chronic myeloid leukemia (CML). It is stated that the break site in various regions is not associated with the disease stage and clinicohematological manifestations in the time of the diagnosis. The break in the 5' subregion was indicative of longer survival than that in the subregion 3' patients. Median survival reached 60.8 and 32.4 months, respectively.