Upon evaluating seasonal shifts in hemostasis in healthy subjects (3200 examinees aged 18-40) it was established that coagulation rate is the highest in spring. This phenomenon occurred in association with activated fibrinolysis, reduced levels of antithrombin III and more marked paracoagulant tests. Natural lysis of the clot and euglobin fibrinolysis proved more intensive in spring, while least intensive in winter. Frequency of clot lysis inhibition varies with season of the year. In winter the inhibition is observed in 45%, in spring in 21.6%, in summer in 41% and autumn in 36.2% of the examinees. The facts allowed the conclusion on more active hemostasis in spring and less active fibrinolysis in winter, this making these seasons in the Middle Russia most risky as regards vascular accidents.
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