Twelve patients with ureteral injuries from stab or gunshot wounds were evaluated. All 12 underwent surgical exploration on admission. None of the injuries were diagnosed preoperatively. Eleven of 12 injuries were diagnosed during surgical exploration. Diagnosis was delayed in one patient, until 2 weeks after injury, when a CT scan revealed a urinoma. High-dose intravenous urograms (IVUs) were nondiagnostic in nine of nine patients. Hematuria was absent in 45% of patients (5 of 11). Repair of ureteral injury was successfully performed on the proximal and middle portions of the ureter (nine patients) with stented ureteroureterostomy. Three patients sustained distal ureteral injuries. Two underwent ureteroneocystostomy and psoas hitch, and one a primary repair. Mean follow-up time after repair was 4 months in nine patients, and only two minor complications were noted. Currently available preoperative methods, including urinalysis and high-dose IVU, are not reliable for detecting penetrating ureteral injury. In addition, 1 of 12 ureteral injuries was not initially identified, despite routine surgical exploration, urinalysis, and high-dose IVU. A high index of suspicion is required to diagnose ureteral injury.
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http://dx.doi.org/10.1097/00005373-199406000-00002 | DOI Listing |
J Feline Med Surg
January 2025
Department of Surgical & Radiological Sciences, University of California-Davis, Davis, CA, USA.
Objectives: Serum galectin-3 (sGal-3) is a protein present in renal tubules and increases in experimental rodent models of acute kidney injury. The aim of this study was to compare sGal-3 concentrations in healthy cats and cats with ureteral obstruction (UO).
Methods: This was a retrospective study.
Cureus
December 2024
Radiology, West Suffolk NHS Foundation Trust, Bury St Edmunds, GBR.
Spontaneous ureteral rupture is a rare cause of acute abdominal pain, particularly unusual during pregnancy or the post-partum period. While pregnancy-related changes like ureteral compression and dilation may play a role, no definitive mechanisms have been established. Clinicians should suspect ureteric injury in post-partum patients with free pelvic fluid.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Introduction: The pathogenesis of renal fibrosis is related to blood stasis, and the method of promoting blood circulation and removing blood stasis is often used as the treatment principle. Danshen injection (DSI) is a commonly used drug for promoting blood circulation and removing blood stasis in clinic. However, whether DSI slows the progression of renal fibrosis or the potential mechanism is uncertain.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, 230601, China.
Background: Renal fibrosis is crucial in the progression of chronic kidney disease (CKD) to end-stage renal failure. Geniposide, an iridoid glycoside, has shown therapeutic potential in acute kidney injury, diabetic nephropathy, and atherosclerosis. The aim of this study was to investigate the role of geniposide in renal fibrosis and its underlying mechanisms.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Renal fibrosis is widely recognized as the ultimate outcome of many chronic kidney diseases. The process of epithelial-mesenchymal transition (EMT) plays a critical role in the progression of fibrosis following renal injury. UHRF1, as a critical epigenetic regulator, may play an essential role in the pathogenesis and progression of renal fibrosis and EMT.
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