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Factors affecting the direct red cell effect on thrombosis: Hematocrit dilution and injury patterns.
J Trauma Acute Care Surg
December 2024
From the Department of Surgery, University of Cincinnati, Cincinnati, Ohio.
Background: Red blood cell (RBC) aggregation can be initiated by calcium and tissue factor, which may independently contribute to microvascular and macrovascular thrombosis after injury and transfusion. Previous studies have demonstrated that increased blood storage duration may contribute to thrombotic events. The aims of this study were to first determine the effect of blood product components, age, and hematocrit (HCT) on the aggregability of RBCs, followed by measurement of RBC aggregability in two specific injury models including traumatic brain injury (TBI) and hemorrhagic shock.
View Article and Find Full Text PDFLimited efficacy of platelet-rich plasma intramatricial injections for idiopathic brittle nail treatment: a pilot intra-subject randomized controlled trial.
J Am Acad Dermatol
January 2025
Weill Cornell Medicine, Department of Dermatology, New York City, USA. Electronic address:
Antibacterial Effect of Canine Leucocyte Platelet-Rich Plasma (L-PRP) and Canine Platelet-Poor Plasma (PPP) Against Methicillin-Sensitive and Methicillin-Resistant .
Vet Sci
December 2024
Veterinary Transfusion Research Laboratory (REVLab), Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
(SP) is a commensal and opportunistic pathogen of skin and mucosal surfaces, isolated from healthy dogs and from canine pyoderma cases. It has recently gained attention due to its increasing antibiotic resistance. Platelet-rich plasma (PRP) is a biological product, obtained through a blood centrifugation process, which has antibacterial properties evidenced by in vitro and in vivo studies conducted in both the human and veterinary field.
View Article and Find Full Text PDFExtracellular vesicles from platelet-poor plasma possess anti-inflammatory and anti-catabolic effects in chondrocytes stimulated with IL-1β or synovial membrane-conditioned media.
J Orthop Surg Res
December 2024
Associated Tissue Bank, Faculty of Medicine, P.J. Safarik University and L. Pasteur University Hospital in Kosice, Tr. SNP 1, Kosice, 04011, Slovakia.
Article Synopsis
- Osteoarthritis (OA) is common and currently lacks effective treatments that can both modulate the immune response and repair cartilage, prompting research into extracellular vesicles (EVs) from blood-derived products like platelet poor plasma (PPP).
- This study examined how PPP-derived EVs affect OA chondrocytes in a lab setting, revealing that these EVs possess anti-inflammatory properties and can significantly reduce the expression of certain inflammatory genes associated with OA.
- The findings suggest that PPP-EVs can potentially be developed as a new type of treatment for OA, offering promise for better management of the disease in the future.
Impaired whole blood thrombin generation is associated with procedure-related bleeding in acutely decompensated cirrhosis.
J Hepatol
December 2024
Department of Medicine (DIMED), University of Padova, Italy; First Chair of Internal Medicine and Thrombotic and Haemorrhagic Disease Unit, Padova University Hospital, Padova, Italy. Electronic address:
Background & Aims: The clinical utility of thrombomodulin-modified thrombin generation (TM-TG) in cirrhosis is uncertain. We conducted a prospective study to evaluate the prognostic value of TM-TG in cirrhosis.
Methods: Patients were recruited during outpatient clinics (compensated and stable decompensated) or if admitted to our inpatient service (acutely decompensated, AD).
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