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Adenovirus Biodistribution is Modified in Sensitive Animals Compared to Naïve Animals.
Mol Biotechnol
April 2020
Department of Molecular Biology and Genomics, Institute for Molecular Biology and Gene Therapy, University of Guadalajara, Sierra Mojada 950, Colonia Independencia, Edificio Q. Tercer Piso, CP 44340, Guadalajara, Jalisco, Mexico.
Pre-existing immune response against adenovirus could diminish transgene expression efficiency when Ad is employed in humans as gene therapy vector. We previously used Ad-hΔuPA (Recombinant adenovirus expressing human urokinase-type plasminogen activator) as antifibrotic gene therapy in cirrhosis models and demonstrated its effectiveness. As a further clinical approach, transient Cyclosporine A (CsA) immunosuppression was induced in cirrhotic animals to determine whether Ad-hΔuPA administration retained efficacy.
View Article and Find Full Text PDFProlonged amelioration of acute lung allograft rejection by sequential overexpression of human interleukin-10 and hepatocyte growth factor in rats.
Exp Lung Res
November 2011
Division of General Thoracic Surgery, University Hospital Bern, University of Bern, Switzerland.
The effect of prolonged electroporation-mediated human interleukin-10 (hIL-10) overexpression 24 hours before transplantation, combined with sequential human hepatocyte growth factor (HGF) overexpression into skeletal muscle on day 5, on rat lung allograft rejection was evaluated. Left lung allotransplantation was performed from Brown-Norway to Fischer-F344 rats. Gene transfer into skeletal muscle was enhanced by electroporation.
View Article and Find Full Text PDFProlonged amelioration of acute lung allograft rejection by overexpression of human interleukin-10 under control of a long acting ubiquitin C promoter in rats.
J Heart Lung Transplant
December 2006
Division of General Thoracic Surgery, University Hospital, Bern, Switzerland.
Background: The prolonged effect of electroporation-mediated human interleukin-10 (hIL-10) overexpression in skeletal muscle under the control of the constitutional polyubiquitin C promoter (pUb hIL-10) on rat lung allograft rejection was evaluated.
Methods: Left lung allotransplantation was performed from Brown-Norway to Fischer-F344 rats. Either 2.
FK506 sensitizes mammalian cells to high osmolarity by modulating p38 MAP kinase activation.
Cell Mol Life Sci
March 2004
Instituto de Investigaciones Biomédicas (CSIC), Madrid, Spain.
The immunosuppressants tacrolimus (FK506) and cyclosporin A (CsA) have increased the survival rates in organ transplantation. Both drugs inhibit the protein phosphatase calcineurin (CaN) in activated T cells, exhibiting similar side-effects. Diabetes is observed more often in FK506 than CsA therapy, probably due to inhibition of new molecular targets other than CaN.
View Article and Find Full Text PDFThe modulatory effect of diltiazem on human in vitro alloreactivity when used alone or in combination with cyclosporin A and/or methylprednisolone.
Transpl Int
February 1998
Laboratorio di Immunologia, Istituto Superiore di Sanità, Rome, Italy.
The calcium channel blocker diltiazem is often included in post-transplant regimens in combination with other immunosuppressive drugs such as cyclosporin A (CyA). It is primarily used because of its antinephrotoxic and antihypertensive effects, so that undesirable side effects induced by the immunosuppressive therapy can be reduced. Its alleged ability to induce direct immunosuppression may explain the encouraging results from its clinical use and would appear to encourage a much wider use of this drug.
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