AI Article Synopsis
- The study found an increase in GABA-immunoreactive cells in the superficial dorsal horn of the rat spinal cord following inflammation induced by a carrageenan injection in the hind foot.
- The rise in GABAergic cells was significant only on the side of the injury and peaked at 23.4% more than the opposite side four days post-injection.
- Interventions like sciatic neurectomy or neonatal capsaicin treatment blocked this increase, suggesting that GABA levels in the dorsal horn are enhanced due to pain signals from unmyelinated C fibers in the inflamed area.
Article Abstract
An increase in the number of gamma-aminobutyric acid (GABA)-immunoreactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection. The rise of GABAergic cells was restricted to the ipsilateral dorsal horn, reaching a peak value of 23.4% over the contralateral side 4 days after carrageenan injection. Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that dorsal horn GABA is up-regulated by the increase of noxious inflow conveyed by unmyelinated C fibers from the inflamed tissues.
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| http://dx.doi.org/10.1016/0304-3959(94)90094-9 | DOI Listing |
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