Baclofen overdose occasionally results in cardiac effects, but serious tachyarrhythmias have not been reported. We present the case of a 21-year-old man with an acute baclofen overdose who developed increased cardiac conduction times and a rapid supraventricular tachyarrhythmia which required medical intervention. Acute baclofen toxicity can result in the development of tachyarrhythmias and cardiac monitoring is warranted in acute overdose states.
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http://dx.doi.org/10.3109/15563659409017961 | DOI Listing |
Clin Toxicol (Phila)
January 2025
Medical Intensive Care Unit, CHU de Rouen, Rouen, France.
Forensic Sci Int
December 2024
National Drug & Alcohol Research Centre, University of New South Wales, NSW 2052, Australia.
BMJ Case Rep
September 2024
Department of Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA
Case Presentation: A woman in her 70s was found unresponsive and brought to our hospital with respiratory distress, cardiomyopathy and volatile alternation between hypotension and hypertension. She was intubated and admitted to intensive care for supportive treatment of suspected baclofen overdose. She gradually recovered and was discharged 10 days after presentation.
View Article and Find Full Text PDFSubst Abuse Rehabil
August 2024
Department of Psychological Science, Northern Kentucky University, Highland Heights, KY, USA.
The illicit use of the psychostimulant methamphetamine (METH) is a major concern, with overdose deaths increasing substantially since the mid-2010s. One challenge to treating METH use disorder (MUD), as with other psychostimulant use disorders, is that there are no available pharmacotherapies that can reduce cravings and help individuals achieve abstinence. The purpose of the current review is to discuss the molecular targets that have been tested in assays measuring the physiological, the cognitive, and the reinforcing effects of METH in both animals and humans.
View Article and Find Full Text PDFNeurosurg Focus
June 2024
1Department of Neurosurgery and.
Objective: Intrathecal baclofen (ITB) pumps are commonly used in pediatric patients with cerebral palsy (CP) and medically refractory spasticity. However, catheter malfunction and associated risk factors are not well understood. The aim of this study was to examine potential risk factors for spinal catheter malfunction and characterize postoperative follow-up to understand the clinical consequences.
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