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[Inherited retinal disorders: clinical and molecular genetic diagnostic].
Klin Monbl Augenheilkd
January 2025
Inherited retinal dystrophies (IRD) are the most frequent cause for severe visual loss in the working age. The heterogeneous group of IRDs is associated with loss of visual function and has a severe impact on personal and familial life. Early diagnosis is of high relevance for patients and their families, to facilitate possible therapies and professional help for the individual situation.
View Article and Find Full Text PDFMetastatic triple-negative breast cancer has a poor prognosis and poses significant therapeutic challenges. Until recently, limited therapeutic options have been available for patients with advanced disease after failure of first-line chemotherapy. The aim of this review is to assess the current evidence supporting second-line treatment options in patients with metastatic triple-negative breast cancer.
View Article and Find Full Text PDFBlarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial.
J Prev Alzheimers Dis
January 2025
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
The environmental impact of inhalers: a framework for sustainable prescription practices in Spain.
Eur J Hosp Pharm
January 2025
Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Background: The healthcare sector contributes significantly to global greenhouse emissions, with inhalers being major contributors.
Objective: To develop a framework for reducing the environmental footprint of inhalers in Spain by implementing greener prescription practices.
Methods: A multidisciplinary working group was formed, including hospital pharmacists, pulmonologists, and environmental experts.
The General Acceptability and Use of Smartphone App-Delivered Interventions for Gambling in Australia.
J Gambl Stud
January 2025
School of Psychology, Deakin University, 221 Burwood Hwy, Burwood, VIC, 3125, Australia.
Smartphones can extend the reach of evidence-based gambling treatment services, yet the general acceptability of app-delivered gambling interventions remains unknown. This study examined the general acceptability and use of app-delivered gambling interventions, and predictors of both, among 173 Australian adults with a lifetime gambling problem (48.5% male, M = 46.
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