This work was aimed at the study of reserve capacities of the insular apparatus of the pancreas during the glucose tolerance test, and the test with tolbutamide and leucine in patients with Itsenko-Cushing's disease. The mentioned patients showed an increase in the immunoreactive insulin (IRI) level on the fasting stomach and a fall of the regulatory capacities of the insular apparatus of the pancreas; this was expressed in a later and high increase in the IRI level during the tests.
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