In chemostat culture, the virulence of two strains of Legionella pneumophila was shown to be significantly (P < 0.05) reduced when the culture temperature was lowered from 37 to 24 degrees C. This modulation was reversed by returning the temperature to 37 degrees C, which resulted in a statistically significant (P < 0.05) increase in virulence.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC302910PMC
http://dx.doi.org/10.1128/iai.62.7.2995-2997.1994DOI Listing

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