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Prenatal Diagnosis of Diastematomyelia: a Case Report and Literature Review.
Reprod Sci
December 2023
Department of Gynecology and Obstetrics, Hospital Universitario Nuestra Señora de Candelaria, Carretera General del Rosario, 145, 38010, Santa Cruz de Tenerife, Spain.
Diastematomyelia is a type of closed spinal dysraphism in which there is splitting of the spinal cord. It is a rare entity that accounts for less than 3% of closed spinal dysraphisms and affects females 1.3 to 6 times more frequently than males.
View Article and Find Full Text PDFRoutine measurement of amniotic fluid alpha-fetoprotein and acetylcholinesterase: the need for a reevaluation.
Am J Obstet Gynecol
August 2014
Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, Los Angeles, CA; Center for Fetal Medicine and Women's Ultrasound, Los Angeles, CA. Electronic address:
Objective: The objective of the study was to evaluate whether the current screening regimen of measuring amniotic fluid alpha-fetoprotein (AF-AFP) at the time of amniocentesis and reflex acetylcholinesterase testing vs ultrasound alone to detect neural tube and ventral wall defects offers improved diagnostic accuracy and cost benefit.
Study Design: A retrospective chart review on all patients who had amniocentesis performed at 1 center over the past 11 years was performed. Those with an elevated AF-AFP were compared with those whose AF-AFP was within normal limits.
Aplasia cutis congenita in a setting of fetus papyraceus associated with small fetal abdominal circumference and high alpha-fetoprotein and amniotic acetylcholinesterase.
Pediatr Dermatol
October 2015
Department of Dermatology, Beth Israel Medical Center, New York, New York; Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York.
Fetus papyraceus is the fetal death of one or more fetuses in a multiparous pregnancy. The surviving infants can experience extensive aplasia cutis in an H-shaped distribution over the flanks and abdomen as a consequence of the loss of their fetal sibling. We report the case of a monochorionic, diamniotic pregnancy complicated by a single fetal death at 13 weeks of gestational age.
View Article and Find Full Text PDFLethal and sub lethal effects of the biocide chlorhexidine on aquatic organisms.
Ecotoxicology
November 2013
Department of Biology and CESAM, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
Chlorhexidine is among the most used biocides in Europe, however its toxicity to aquatic organisms is scarcely known. The main objective of this study was to assess the lethal and sub lethal effects of chlorhexidine digluconate (ChD) on four aquatic model organisms: the bacteria Vibrio fischeri, the algae Pseudokirchneriella subcapitata, the crustacean Daphnia magna and the embryos of the fish Danio rerio. ChD was very toxic to algae and crustaceans, with a 72 h-EC50 of 62.
View Article and Find Full Text PDFAmniotic fluid glial fibrillary acidic protein (AF-GFAP), a biomarker of open neural tube defects.
Prenat Diagn
October 2013
Centre de Recherche en Cancérologie de Lyon, Université Lyon 1 - Inserm U1052 - CNRS UMR5286 - Centre Léon Bérard, Lyon, France; Hospices Civils de Lyon, Hôpital de la Croix Rousse, Lyon, France; UFR de Médecine Lyon Sud, Université de Lyon, Lyon, France.
Objective: Neural tube defects (NTDs) are usually identified by ultrasonography and confirmed by alpha-fetoprotein (AFP) assay and acetylcholinesterase (AchE) electrophoresis in amniotic fluid. Yet, both of these biomarkers can be found positive in other etiologies. Here, amniotic fluid glial fibrillary acidic protein (AF-GFAP), which was identified by a proteomic study, is shown to be a useful biomarker for NTD diagnosis.
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