The beam characteristics of the wedged fields in the nonwedged planes (planes normal to the wedged planes) were studied for 6 MV and 15 MV x-ray beams. A method was proposed for determining the maximum field length of a wedged field that can be used in the nonwedged plane without introducing undesirable alterations in the dose distributions of these fields. The method requires very few measurements. The relative wedge factors of 6 MV and 15 MV X-rays were determined for wedge filters of nominal wedge angles of 15 degrees, 30 degrees, 45 degrees, and 60 degrees as a function of depth and field size. For a 6 MV beam the relative wedge factors determined for a field size of 10 x 10 cm2 for 30 degrees, 45 degrees, and 60 degrees wedge filters can be used for various field sizes ranging from 4 cm2 to 20 cm2 (except for the 60 degrees wedge for which the maximum field size that can be used is 15 x 20 cm2) without introducing errors in the dosimetric calculations of more than 0.5% for depths up to 20 cm and 1% for depths up to 30 cm. For the 15 degrees wedge filter the relative wedge factor for a field size of 10 x 10 cm2 can be used over the same range of field sizes by introducing slightly higher error, 0.5% for depths up to 10 cm and 1% for depths up to 30 cm. For a 15 MV beam the maximum magnitude of the relative wedge factors for 45 degrees and 60 degrees lead wedges is of the order of 1%, and it is not important clinically to apply a correction of that magnitude. For a 15 MV beam the relative wedge factors determined for a field size of 6 x 6 cm2 for the 15 degrees and 30 degrees steel wedges can be used over a range of field sizes from 4 cm2 to 20 cm2 without causing dosimetric errors greater than 0.5% for depths up to 10 cm.
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http://dx.doi.org/10.1016/0958-3947(94)90031-0 | DOI Listing |
Ecotoxicol Environ Saf
January 2025
Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, China. Electronic address:
Habitat fragmentation represents a multifaceted global conservation threat, exerting both direct and indirect effects on individual animals and communities. Reptiles, particularly smaller species with limited migratory abilities, are especially vulnerable to these changes. This study examines how small reptiles adapt their life history strategies in fragmented habitats and determines whether their responses are primarily due to phenotypic plasticity or genetic adaptation.
View Article and Find Full Text PDFNanotechnology
January 2025
Walker Department of Mechanical Engineering, The University of Texas at Austin, 204 E. Dean Keeton St., Austin, Texas, 78712-1139, UNITED STATES.
Sapphire is an attractive material in photonic, optoelectronic, and transparent ceramic applications that stand to benefit from surface functionalization effects stemming from micro/nanostructures. Here we investigate the use of ultrafast lasers for fabricating nanostructures in sapphire by exploring the relationship between irradiation parameters, morphology change, and selective etching. In this approach an ultrafast laser pulse is focused on the sapphire substrate to change the crystalline morphology to amorphous or polycrystalline, which is characterized by examining different vibrational modes using Raman spectroscopy.
View Article and Find Full Text PDFJ Neurosurg
January 2025
1Department of Neurosurgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Objective: The purpose of this study was to present a newly designed 3D-printed personalized model (3D PPM) of a radiofrequency needle guide with a maxillary fixation for gasserian ganglion (GG) puncture.
Methods: Implementation of 3D CT-guided radiofrequency therapy of the GG with and without use of 3D PPM was analyzed. The following parameters were assessed: radiation time, dose area product, air kerma reference point, pain severity during the puncture needle insertion, prosopalgia regression degree (according to visual analog scale) and the severity of facial numbness (according to the Barrow Neurological Institute scale) in the early postoperative period, and postpuncture complications.
PLoS One
January 2025
Prince Mohammad Bin Fahd University, Al Khobar, Saudi Arabia.
Topological indices are crucial tools for predicting the physicochemical and biological features of different drugs. They are numerical values obtained from the structure of chemical molecules. These indices, particularly the degree-based TIs are a useful tools for evaluating the connection between a compound's structure and its attributes.
View Article and Find Full Text PDFPLoS Pathog
January 2025
Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
IKKε is a traditional antiviral kinase known for positively regulating the production of type I interferon (IFN) and the expression of IFN-stimulated genes (ISGs) during various virus infections. However, through an inhibitor screen targeting cellular kinases, we found that IKKε plays a crucial role in the lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV). Mechanistically, during KSHV lytic replication, IKKε undergoes significant SUMOylation at both Lys321 and Lys549 by the viral SUMO E3 ligase ORF45.
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