The effects of oleic and elaidic acid upon the in vitro intestinal uptake of cholesterol were studied in 9 weeks-old male and female rats. Elaidic acid increases the uptake of cholesterol when compared to oleic acid in both males and females. It is suggested that elaidic acid may enhance the esterification of cholesterol within the enterocyte through being more available for esterification and/or through being preferentially incorporated into cholesterol esters.
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http://dx.doi.org/10.3109/13813459409007544 | DOI Listing |
Diabetologia
January 2025
MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Aims/hypothesis: UK standard care for type 2 diabetes is structured diabetes education, with no effects on HbA, small, short-term effects on weight and low uptake. We evaluated whether remotely delivered tailored diabetes education combined with commercial behavioural weight management is cost-effective compared with current standard care in helping people with type 2 diabetes to lower their blood glucose, lose weight, achieve remission and improve cardiovascular risk factors.
Methods: We conducted a pragmatic, randomised, parallel two-group trial.
Food Chem
January 2025
Department of Food Science, College of Light Industry, Liaoning University, Shenyang 110031, Liaoning Province, China; State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning Province, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi Province, China. Electronic address:
Deep-fat frying (DF) of mushrooms is favored by consumers due to its appealing sensory characteristics. However, their high oil absorption can lead to obesity and elevated cholesterol levels. Therefore, developing healthy food coatings as oil barriers and water-holding layers is essential.
View Article and Find Full Text PDFBiomacromolecules
January 2025
Department of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.
Engineered natural killer (NK) cells eliminate cancer cells by overexpressing a chimeric antigen receptor, producing highly efficient and safe NK cell therapies. This study investigated the polyplex formulation for the fusion protein GreenLantern-natural killer group 2D (NKG2D) mRNA to evaluate its delivery efficacy into NK cells, wherein NKG2D on the surface of NK cells recognized its counterpart NKG2D ligands on cancer cells. Amphiphilic polyaspartamide derivatives Chol-PAsp(DET/CHE) were prepared by adding cyclohexylethylamine (CHE) and diethylenetriamine (DET) in the side chains and cholesterol (Chol) at the α-terminus to enhance endosomal escapability and optimize hydrophobicity.
View Article and Find Full Text PDFFront Pharmacol
January 2025
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. Cholesterol regulation by saponins is a complex process that involves multiple mechanisms.
View Article and Find Full Text PDFBMJ Open Diabetes Res Care
January 2025
The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong, China
Introduction: Type 2 diabetes (T2D) is a chronic condition characterized by high levels of blood glucose resulting from the inefficiency of insulin. This study aims to explore the mechanism of TGFB-induced factor homeobox 1 (TGIF1) in the glycolipid metabolism of mice with T2D.
Research Design And Methods: Mice with T2D were induced by high-fat diet and low-dose streptozotocin (STZ) injection.
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