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Exploratory study of erosion in cultivated organic soils using cesium-137 measurements.
J Environ Radioact
December 2024
Département des sols et de génie agroalimentaire, Faculté des sciences de l'agriculture et de l'alimentation, Université Laval, 2325 Rue de l'Université, G1V 0A6, Québec, (QC), Canada.
Concerns about the sustainability of cultivated organic soils in Montérégie (Quebec, Canada), which can also be identified as histosols, led to this exploratory study aimed at quantifying erosion in these soils by using cesium-137 (Cs) measurements. Soil samples were taken from organic soils in twenty-two fields, and their Cs contents were measured by gamma spectrometry. The estimated mean annual erosion rates (±SD), adjusted with cropping history, ranged from 0.
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Therapie
January 2023
Service de pharmacologie et centre régional de pharmacovigilance, hôpital Pitié-Salpêtrière, groupe hospitalier, AP-HP, Sorbonne université, 75013 Paris, France.
Drug repurposing: From the discovery of a useful pharmacological effect to making the treatment available to the patient.
Therapie
January 2023
Service de pharmacologie et centre régional de pharmacovigilance, hôpital Pitié-Salpêtrière, groupe hospitalier, AP-HP, Sorbonne université, 75013 Paris, France.
Article Synopsis
- - Repurposing existing medicines can quickly address unmet therapeutic needs, especially for rare diseases and health emergencies, but challenges can prevent drugs from reaching patients.
- - Obstacles in accessing drug data and complex clinical trial processes can hinder the successful repurposing of drugs, even if promising results are found.
- - To effectively overcome these challenges, the discussion emphasized the need for public-private partnerships that provide adequate funding and support for drug repurposing projects through to marketing approval.
Altered expression of miR-29a-3p and miR-34a-5p by specific inhibition of GSK3β in the MPP treated SH-SY5Y Parkinson's model.
Noncoding RNA Res
March 2022
Department of Medical Biotechnology, National Research Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
In the current study, the effects of 7-BIO as a specific GSK3β inhibitor was examined on cell survival and expression of miR-29a-3p and miR-34a-5p in neurotoxin MPP treated SH-SY5Y cells. Our findings revealed that while co-treatment of the cells with 7-BIO and MPP did not alter the toxicity induced by MPP, pretreatment with 3.5 μM 7-BIO for 6 h increased the survival of the 2 mM MPP treated cells.
View Article and Find Full Text PDFExploiting the preferential phagocytic uptake of nanoparticle-antigen conjugates for the effective treatment of autoimmunity.
Nanomedicine
February 2022
Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India. Electronic address:
Tolerance induction is central to the suppression of autoimmunity. Here, we engineered the preferential uptake of nano-conjugated autoantigens by spleen-resident macrophages to re-introduce self-tolerance and suppress autoimmunity. The brain autoantigen, myelin oligodendrocyte glycoprotein (MOG), was conjugated to 200 or 500 nm silica nanoparticles (SNP) and delivered to the spleen and liver-resident macrophages of experimental autoimmune encephalomyelitis (EAE) mice, used as a model of multiple sclerosis.
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