The mesenchymal repair process of the connective tissue in the surgical wound following lumbar laminectomy presents three aspects: postoperative epidural scar, heterotopic bone formation in the epidural scar and vertebral hyperostosis around laminectomy. Twelve cases of lumbar spine hyperostosis consecutive to laminectomy, confirmed by x-ray findings and surgery are presented. The main symptom at presentation was a recurrent sciatic neuritis. Lumbo-sacral spine films showed a "bright" focal condensation in the previous surgical. Lamina inferior and superior and the articular facets were hypertrophic. Surgery confirmed the hyperostosis and compressive lumbar spine stenosis or foramen stenosis.
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Article Synopsis
- In a study involving rats, researchers tested the effects of esomeprazole on excessive scarring after laminectomy surgery.
- The experiment included three groups: a control group with no treatment, a local esomeprazole group with topical application, and a systemic esomeprazole group receiving the drug intraperitoneally.
- Results showed that esomeprazole significantly reduced macroscopic and microscopic epidural fibrosis compared to the control group, indicating its potential benefit in preventing scar formation after surgery.
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