Among the multiple aspects about which little is still known about Raynaud's phenomenon (RP), is that, in the author's opinion, regarding the question: how many and which patients are sufficiently troubled by this pathology to seek medical treatment from their own GP or specialist, and what are the results of any treatment commenced. The following questions were put to a group of 180 patients affected by RP attending the out-patient clinic for the first time: 1) how many had already received treatment; 2) which patients were receiving pharmacological treatment and/or had undergone surgery. In this context, the authors assessed the influence of the following parameters on the fact that they had or had not been treated: a) the age of patients; b) the duration of disease; c) the presence of stenosing or obliterating arterial lesions (RP on an organic basis); d) the co-presence of pathologies considered to be the possible etiological cause of RP in literature; e) the severity of symptoms; 3) what results were obtained by medical and/or surgical treatment; 4) what was the course of RP which failed to respond to therapeutic measures. The study examined a series of 180 subjects including 139 (77.22%) females (mean age 47.6% years) and 41 (22.78) males (mean age 42.4 years). Symptoms had been present for a period ranging between 2 and 44 years (mean 10.01). In order to ascertain the possible presence of associated diseases considered by many authors to be causal factors, all patients underwent hemotochemical and instrumental test.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cureus
December 2024
General Surgery, Mercy General Hospital, Sacramento, USA.
Botulinum toxin (BoNT) has traditionally been utilized to relieve tension in muscular and connective tissue diseases (CTD). However, its usage has rapidly expanded and now encompasses usage for neurological, gastrointestinal, psychological, cardiovascular, ophthalmology, orthopedics, and more. More recently, its usage has been utilized for sequelae of CTDs such as Raynaud's disease and reduced oral aperture secondary to scleroderma/systemic sclerosis.
View Article and Find Full Text PDFProg Cardiovasc Dis
January 2025
Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:
Raynaud's phenomenon (RP) is a vascular disease characterized by exaggerated vasoconstriction in response to stressors, mainly cold and emotional stress. This vasoconstriction is mediated solely by alpha 2C-adrenoceptors (α-AR) expressed in vascular smooth muscle cells of dermal arterioles. Several factors, among which is cigarette smoking, are associated with aggravated symptoms of and increased risk for RP.
View Article and Find Full Text PDFInt J Rheum Dis
January 2025
Systemic Autoimmune Diseases Unit, Department of Medicine IV, Fernando Fonseca Hospital, Amadora, Portugal.
BMC Rheumatol
January 2025
Montefiore Medical Center, Albert Einstein College of Medicine, Rheumatology, Bronx, NY, USA.
Background: The anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody-positive dermatomyositis is known for its association with rapidly progressive interstitial lung disease (RP-ILD) and ulcerative skin lesions, often presenting with or without muscle involvement. The aim of this study was to identify distinct clinical and laboratory features that could be used to evaluate disease progression in an ethnically diverse cohort of anti-MDA5 dermatomyositis patients at a U.S.
View Article and Find Full Text PDFAm J Ind Med
January 2025
Occupational Cancer Research Centre, Ontario Health, Toronto, Ontario, Canada.
Introduction: Raynaud's phenomenon (RP) is linked to occupational exposures such as vibration, cold temperature, and chemicals. However, large cohort studies examining RP by occupation and sex are scarce. To address this gap, this study aimed to assess risk of RP by both occupation and sex in a large cohort of workers in Ontario, Canada.
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