Unlabelled: To develop an automated image interpretation system of planar cardiac 201Tl dipyridamole stress/redistribution scintigrams, the authors used artificial neural networks that associate patterns of segmental myocardial thallium uptake with a diagnostic assessment about the presence, severity and localization of significant coronary artery disease.
Methods: Artificial neural networks were trained and evaluated using the results from segmental thallium analysis and either expert readings in 159 cases or coronary angiography in a subgroup of 81 patients.
Results: Based on receiver operating characteristics analysis, the sensitivity for the detection of significant coronary artery disease at a specificity of 90% was 51% compared with angiography and 72% compared with the human expert. For severity and localization of disease, two vascular territories assigned to the vascular bed of the left anterior descending (LAD) artery and to the territory subtended by the left circumflex artery and the right coronary artery together (CX/RCA) were included in the analysis.
Conclusion: Artificial neural networks may be useful to develop automated computer-based image interpretation systems of 201Tl perfusion scintigrams. However, utilization of large training datasets appears to be a prerequisite to achieve adequate diagnostic performance.
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