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The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review.
Front Pharmacol
January 2025
Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, China.
Objective: Several antifungals are available for the treatment of patients with invasive aspergillosis (IA). This study aims to evaluate the relative efficacy and safety of the first-line monotherapies in primary therapy of IA through network meta-analysis (NMA).
Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP database, Wanfang database, and China Biology Medicine for randomized controlled trials (RCTs) up to July 2023 that evaluated the efficacy and safety of monotherapies.
Antifungal-drug interactions in oncology: A cross-sectional study highlighting the role of pharmacists.
J Oncol Pharm Pract
January 2025
Department of Pharmacy, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Study Objective: Complex pharmacotherapy in cancer patients increases the likelihood of drug-drug interactions (DDIs). Pharmacists play a critical role in the identification and management of DDIs. The aim of present study was to evaluate the role of pharmacist in identifying antifungal drug interactions in cancer patients and providing relevant recommendations.
View Article and Find Full Text PDFDonor-derived Cryptococcus gattii complex infection after liver transplantation.
Rev Soc Bras Med Trop
January 2025
Universidade Federal do Paraná, Departamento de Clínica Médica, Programa de pós-graduação em Medicina Interna e Ciências da Saúde, Curitiba, PR, Brasil.
Cryptococcal disease is the third most common invasive fungal infection in solid organ transplant recipients and is associated with high-morbidity and -mortality rates. Donor-derived Cryptococcus spp. infection typically manifests within the first month post-procedure and has historically been caused by C.
View Article and Find Full Text PDFIntracameral voriconazole for severe fungal keratitis: a case series.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: This study aimed to report the use, efficacy, and safety of intracameral voriconazole as an adjuvant treatment for deep fungal keratitis.
Methods: This was a prospective case series of seven eyes with fungal keratitis with anterior chamber involvement or a corneal ulcer refractory to conventional topical treatment. In addition to topical treatment with 0.
[Investigation of the Antifungal Susceptibility and Virulence Factors of Fusarium Strains Isolated from Clinical Samples].
Mikrobiyol Bul
January 2025
Aydın Adnan Menderes Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Aydın.
Fusarium türleri, insanlarda keratit ve onikomikoz başta olmak üzere invaziv veya invaziv olmayan çeşitli enfeksiyonlarda etken olan küf mantarlarıdır. Taksonomide Fusarium cinsi, tür kompleks [species complex (SC)]'lere ayrılmış, SC'ler de türlere ayrılmıştır. SC/tür düzeyinde identifikasyonun, morfolojik özelliklere göre yapılmasının güçlüğü nedeniyle moleküler yöntemlerin kullanımı önerilmektedir.
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