An immunological study has been made in 47 hemophiliacs with arthropathies receiving local invasive therapy. Joint contents were examined in 20 patients with acute hemarthrosis, 10 patients with exudative synovitis and 11 ones with proliferative synovitis. Under the protection of cryoprecipitate (5 U/kg) all the patients underwent joint puncture with removal of the contents, lavage of the synovial cavity and intraarticular injection of 50 mg of hydrocortisone. Arthropathy activity proved most active in patients with proliferative synovitis. Introduction of local invasive therapy early in hemarthrosis course arrests immune inflammation. Delayed punctures are less effective. Local immunological responses, as shown by repeated punctures, noticeably reduced, at puncture 3-4 the contents were small, immune complexes and immunoglobulins decreased significantly.
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