Sixty four adult patients of both genders with injuries such as contusions and sprains were studied. Of these, 34 were treated with 10% naproxen gel and 30 with 1% dichlophenaco gel topically given for 4 days. Various pain modalities, edema and functional alterations of areas involved were studied. Naproxen reduced spontaneous pain slightly better than dichlophenaco. Both drugs resulted in significant reduction of other pain modalities, edema and functional alterations (p < 0.001). A lower percentage (29%) of naproxen patients used paracetamol as additional pain reliever compared to dichlophenaco patients (36%). Local adverse events were minimum for both groups.

Download full-text PDF

Source

Publication Analysis

Top Keywords

naproxen gel
8
pain modalities
8
modalities edema
8
edema functional
8
functional alterations
8
single blind
4
blind study
4
study evaluate
4
evaluate efficacy
4
efficacy safety
4

Similar Publications

Investigating the application of novel filling materials in Vertical Subsurface Flow Constructed Wetlands for the treatment of anaerobic effluents originating from domestic wastewater.

J Environ Manage

January 2025

Sanitary Engineering Laboratory, Department of Water Resources and Environmental Engineering, School of Civil Engineering, National Technical University of Athens, 9 Iroon Polytechniou St., Zographou Campus, 15773, Athens, Greece.

Vertical subsurface flow constructed wetlands (VSSF CWs) were employed to investigate the use of biochar that could be produced with local agricultural biomass through pyrolysis, recycled glass from local recycling companies and gel beads with decreased packing volume and shipping cost as substrate alternatives to sand. The materials were assessed in terms of granulometry, porosity, adsorption capacity and hydraulic conductivity and were used for the treatment of an upflow anaerobic sludge blanket (UASB) reactor, treating domestic wastewater, effluent. Granulometry was a major factor impacting TSS removal that ranged from 81% ± 10% to 97% ± 2%.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers developed a self-drug-delivery system using a supramolecular gelator called NAP-PHE∙PEA, derived from naproxen and amino acids, capable of gelling both water and organic solvents.* -
  • The study explored the molecular interactions governing the gel's formation using techniques like 1H-NMR spectroscopy and X-ray diffraction to understand the gel-network structure and analyze various salt forms.* -
  • NAP-PHE∙PEA demonstrated strong anti-cancer effects on certain cancer cell lines without harming normal cells, and its gel form exhibited beneficial properties such as self-healing and load-bearing, making it suitable for topical treatments.*
View Article and Find Full Text PDF

Electrical Conductivity as an Informative Factor of the Properties of Liposomal Systems with Naproxen Sodium for Transdermal Application.

Materials (Basel)

November 2024

Clinical Department of Oncodermatology, University Centre of General Dermatology and Oncodermatology, Wroclaw Medical University, Borowska 213, 50-556 Wrocław, Poland.

Liposomal preparations play an important role as formulations for transdermal drug delivery; however, the electrical conductivity of these systems is sparingly evaluated. The aim of the study was to outline the range of the values of electrical conductivity values that may be recorded in the future pharmaceutical systems in the context of their viscosity. The electrical conductivity, measured by a conductivity probe of k = 1.

View Article and Find Full Text PDF

This study investigates the various methods of pain management during the insertion of intrauterine devices (IUDs) in nulliparous women. Currently, the only recommended method of pain management is 800 mg of ibuprofen taken one hour before insertion of the IUD. However, women continue to experience pain during the procedure.

View Article and Find Full Text PDF
Article Synopsis
  • A new low-molecular-weight gelator (LMWG) made from a modified amino acid and an aldehyde can incorporate different active pharmaceutical ingredients (APIs) in distinct ways.
  • Basic APIs like propranolol and atropine can mix with the gelator before it forms a gel, while acidic APIs like naproxen and rosuvastatin disrupt its bonding and must be incorporated afterward.
  • Atropine showed effective release properties and holds promise for use in treating conditions like myopia, indicating the potential for further research and development using these supramolecular gels.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!