A program HEPATOX has been devised for the study of the frequency of hepatic dysfunction signs within the system of data base control FoxPro. The analysis of the data available for 377 tuberculous patients showed a more important role of the laboratory diagnosis compared to clinical symptoms, a predisposing role of prior hepatitides and active inflammation in the onset of hepatic dysfunction in conditions of on-going chemotherapy. The authors present the frequency spectrum for clinical and laboratory findings from tuberculous in patients with liver dysfunctions. The efficacy of computers in phthisiopulmonology is demonstrated.
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Orthop Surg
January 2025
Orthopedics Department, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Objective: Soft tissue defects and postoperative wound healing complications related to calcaneus fractures may result in significant morbidity. The aim of this study was to investigate whether percutaneous minimally invasive screw internal fixation (PMISIF) can change this situation in the treatment of calcaneal fractures, and aimed to explore the mechanical effects of different internal fixation methods on Sanders type III calcaneal fractures through finite element analysis.
Methods: This retrospective analysis focused on 83 patients with Sanders II and III calcaneal fractures from March 2017 to March 2022.
Crit Care
January 2025
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Background: Carbapenem-Resistant Gram-Negative Bacteria, including Carbapenem-Resistant Enterobacterales (CRE) and Carbapenem-Resistant Pseudomonas aeruginosa (CRPA), are common causes of infections in intensive care units (ICUs) in Italy.
Objective: This prospective observational study evaluated the epidemiology, management, microbiological characterization, and outcomes of hospital-acquired CRE or CRPA infections treated in selected ICUs in Italy.
Methods: The study included patients with hospital-acquired infections due to CRE and CRPA treated in 20 ICUs from June 2021 to February 2023.
BMC Psychiatry
January 2025
Department of Psychology, Division of Clinical Psychology and Psychotherapy, Bielefeld University, P.O. Box 100131, Universitätsstraße 25, Bielefeld, 33501, Germany.
Background: The impact of childhood cancer extends beyond the affected child, significantly influencing the mental health of their families. Since research in psycho-oncology has been carried out almost exclusively in high-income countries, little is known about the impact of childhood cancer on the family level in low- and middle income countries (LMICs). This is a notable gap in the evidence-base, as many LMICs are collectivist cultures, where social and family networks are crucial elements of health care.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
January 2025
Department of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, University of KwaZulu- Natal, Durban, South Africa.
Purpose: To explore available literature on PNS mucoceles and its distortions of craniofacial-orbital anatomy with regard to orbital bony defects and ophthalmic manifestations, highlighting the PNS mucoceles that mostly result in these distortions.
Methods: A comprehensive literature search was conducted in June 2024 for available literature on the subject matter viz.; Google Scholar, PubMed and Medline, and Cochrane Library.
Nat Commun
January 2025
National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Epitranscriptomic modifications, particularly N6-methyladenosine (mA), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and translation. Traditional computational methods for detecting mA from Nanopore direct RNA sequencing (DRS) data are constrained by their reliance on experimentally validated labels, often resulting in the underestimation of modification sites. Here, we introduce pum6a, an innovative attention-based framework that integrates positive and unlabeled multi-instance learning (MIL) to address the challenges of incomplete labeling and missing read-level annotations.
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