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Rapid Recognition and Monitoring of Multiple Core Biomarkers with Point-of-Care Importance through Combinatorial DNA Logic Operation.
Anal Chem
January 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun 130012, China.
The early diagnosis of a disease relies on the reliable identification and quantitation of multiple core biomarkers in real-time point-of-care (POC) testing. To date, most of the multiplex photoelectrochemical (PEC) assays are inaccessible to home healthcare due to cumbersome steps, long testing time, and limited detection efficiency. The rapid and fast-response generation of independent photocurrent for multiple targets is still a great challenge.
View Article and Find Full Text PDFAn Ultrasensitive Duplex Aptasensor Featuring the Target-Triggered Lanthanide Luminescence Antenna Effect for Wash-Free Detection of Epithelial Cancerous Exosomes.
ACS Sens
January 2025
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China.
Fluorescence sensing is widely used in in vitro detection due to its high sensitivity and rapid result delivery. However, detection systems based on nanomaterials involving complex and cumbersome purification steps can lead to sample loss and significantly reduce the accuracy of the results. To address this issue, we proposed a lanthanide-based aptasensor featuring the target-triggered antenna effect to significantly enhance the time-resolved luminescence (TRL) of chelated Tb combined with a wash-free strategy.
View Article and Find Full Text PDFThe value of nonenhanced magnetic resonance imaging (MRI) in the grading of primary lower extremity lymphedema.
J Vasc Surg Venous Lymphat Disord
January 2025
Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, China. Electronic address:
Objective: The International Society of Lymphology (ISL) proposed a grading standard for lymphedema in 2020 based on the percent increase in the volume of the affected limb compared to that of the healthy limb. However, this method is cumbersome and time-consuming to measure and calculate, and a standardized formula across different institutions is not available. Therefore, the aim of this study was to investigate the value of nonenhanced MRI for grading primary lower extremity lymphedema (PLEL).
View Article and Find Full Text PDFA Paradigm of Computer Vision and Deep Learning Empowers the Strain Screening and Bioprocess Detection.
Biotechnol Bioeng
January 2025
State Key Laboratory of Bioreactor Engineering, Qingdao Innovation Institute of East China University of Science and Technology, East China University of Science and Technology, Shanghai, China.
High-performance strain and corresponding fermentation process are essential for achieving efficient biomanufacturing. However, conventional offline detection methods for products are cumbersome and less stable, hindering the "Test" module in the operation of "Design-Build-Test-Learn" cycle for strain screening and fermentation process optimization. This study proposed and validated an innovative research paradigm combining computer vision with deep learning to facilitate efficient strain selection and effective fermentation process optimization.
View Article and Find Full Text PDFThe "prostate-pelvic syndrome" theory used in patients with type-III prostatitis and its correlation with prostate volume.
BMC Urol
January 2025
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, 230022, China.
Background: Type-III prostatitis is the most common prostate disease in adult males below 40 years old. The actual operation of its diagnosis process is cumbersome. Recently, a group of top Chinese urologists have proposed the theory of "prostate-pelvic syndrome (PPS)" and suggested using it to replace the traditional term for type-III prostatitis.
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