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Decreased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment for depression in Alzheimer's disease: a functional near-infrared spectroscopy study.
Front Aging Neurosci
January 2025
Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, China.
Background: Studies have shown the clinical effects of repetitive transcranial magnetic stimulation (rTMS) on depression in Alzheimer's disease (AD). However, the underlying mechanisms remain poorly understood. The measurement of brain activation links neurobiological and functional aspects but is challenging in patients with dementia.
View Article and Find Full Text PDFEarly postnatal NMDA receptor ablation in cortical interneurons impairs affective state discrimination and social functioning.
Neuropsychopharmacology
January 2025
Grupo de Neurociencia de Sistemas, Departamento de Ciencias Fisiológicas, Facultad de Ciencias Médicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
Emotion recognition is fundamental for effective social interactions among conspecifics. Impairments in affective state processing underlie several neuropsychiatric disorders, including schizophrenia, although the neurobiological substrate of these deficits remains unknown. We investigated the impact of early NMDA receptor hypofunction on socio-affective behaviors.
View Article and Find Full Text PDFBrain-derived neurotrophic factor alterations and cognitive decline in schizophrenia: Implications for early intervention.
World J Psychiatry
January 2025
Department of Digital Anti-aging Healthcare (BK21), Inje University, Gimhae 50834, South Korea.
This manuscript explores the recent study by Cui which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor (BDNF) levels in first-episode schizophrenia patients. The study revealed that higher levels of interleukin-6 and tumor necrosis factor-α correlated with reduced BDNF levels and poorer cognitive performance. Schizophrenia is a severe psychiatric disorder impacting approximately 1% of the global population, characterized by positive symptoms (hallucinations and delusions), negative symptoms (diminished motivation and cognitive impairments) and disorganized thoughts and behaviors.
View Article and Find Full Text PDFNeuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study.
Psychiatry Clin Neurosci
January 2025
Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kochi, Japan.
Aim: Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, the underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging-derived brain-age estimation by machine-learning analysis has shown promise as an individual-level biomarker. We investigated the relationship between NPS and brain-age in amnestic mild cognitive impairment (MCI) and early dementia.
View Article and Find Full Text PDFSex differences in resting-state fMRI functional connectivity related to humor styles.
Biol Psychol
January 2025
Department of Educational Psychology and Counseling, National Taiwan Normal University, Taipei 106308, Taiwan; Institute for Research Excellence in Learning Sciences, National Taiwan Normal University, Taipei 106308, Taiwan; Chinese Language and Technology Center, National Taiwan Normal University, Taipei 106308, Taiwan; Social Emotional Education and Development Center, National Taiwan Normal University, Taipei 106308, Taiwan. Electronic address:
Research on how functional connectivity (FC) during resting-state relates to humor styles and sex is limited. This study aimed to address this knowledge gap by analyzing resting-state fMRI data from 56 healthy participants and measuring FC. In addition, participants completed the Humor Styles Questionnaire.
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