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Recent Advances in Ocular Drug Delivery: Insights into Lyotropic Liquid Crystals.
Pharmaceuticals (Basel)
October 2024
School of Pharmacy, Department of Pharmaceutical Sciences, The University of Jordan, Amman 11196, Jordan.
This review examines the evolution of lyotropic liquid crystals (LLCs) in ocular drug delivery, focusing on their ability to address the challenges associated with traditional ophthalmic formulations. This study aims to underscore the enhanced bioavailability, prolonged retention, and controlled release properties of LLCs that significantly improve therapeutic outcomes. This review synthesizes data from various studies on both bulk-forming LLCs and liquid crystal nanoparticles (LCNPs).
View Article and Find Full Text PDFLongitudinal Associations of Aerobic Activity, Muscle-Strengthening Activity, and Adiposity with Cardiorespiratory Fitness.
Med Sci Sports Exerc
October 2024
Department of Research, The Cooper Institute, Dallas, TX.
Purpose: Cardiorespiratory fitness (CRF) declines with age, and greater declines increase the risk for adverse health outcomes. Understanding factors that attenuate age-related decreases in CRF can help extend healthy life. We sought to determine the longitudinal associations of aerobic physical activity, muscle-strengthening activity (MSA), and adiposity with CRF.
View Article and Find Full Text PDFQuantifying Active and Passive Stiffness in Plantar Flexor Muscles Following Intermittent Maximal Isometric Contractions Using Shear Wave Elastography.
Ultrasound Med Biol
December 2024
University of Paris Est Creteil, BIOTN, Creteil, France. Electronic address:
Objective: This study aimed: (i) to investigate the impact of fatigue, triggered by maximal isometric contraction exercises, on the active and passive stiffness of plantar flexors (PF), and (ii) to examine the relationship between changes in mechanical parameters and neuromuscular alterations after fatigue.
Methods: A healthy cohort (n = 12; age = 27.3 ± 5.
Dietary patterns and cardiorespiratory fitness in midlife and subsequent all-cause dementia: findings from the cooper center longitudinal study.
Int J Behav Nutr Phys Act
September 2024
The Cooper Institute, 12330 Preston Rd, Dallas, TX, 75230, USA.
Background: Identifying lifestyle factors that independently or jointly lower dementia risk is a public health priority given the limited treatment options available to patients. In this cohort study, we examined the associations between Mediterranean or Dietary Approaches to Stop Hypertension (DASH) diet adherence and cardiorespiratory fitness (CRF) with later-life dementia, and assessed whether the associations between dietary pattern and dementia are modified by CRF.
Methods: Data are from 9,095 adults seeking preventive care at the Cooper Clinic (1987-1999) who completed a 3-day dietary record and a maximal exercise test.
Lysine-Cysteine-Serine-Tryptophan inserted into the DNA-binding domain of human mineralocorticoid receptor increases transcriptional activation by aldosterone.
J Steroid Biochem Mol Biol
October 2024
Division of Nephrology-Hypertension, Department of Medicine, 0693, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA; Center for Academic Research and Training in Anthropogeny (CARTA) University of California, La Jolla, San Diego, CA 92093, USA. Electronic address:
Due to alternative splicing in an ancestral DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW). Human MRs also contain mutations at two sites, codons 180 and 241, in the amino terminal domain (NTD). Together, there are five distinct full-length human MR genes in GenBank.
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