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Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism.
Front Pharmacol
January 2025
Drug and food resources development laboratory, Yunnan University of Traditional Chinese Medicine, Kunming, China.
Objective: This study aims to investigate the preventive effect of walnut oil as medicinal food on abnormal lipid metabolism and its influence on liver metabolites and intestinal flora.
Methods: The rat model of abnormal lipid metabolism was established by feeding high-fat diet and administering a high-fat emulsion via gavage. The rats were randomly assigned to one of the five groups: the normal group (ND), the model group (HFD), and three walnut oil intervention groups differing in dosage [low-dose (OL, 2.
Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.
Int J Biol Macromol
January 2025
Department of Cardiovascular Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China. Electronic address:
The functional food application of edible fungus polysaccharides has been widely studied based on their variety of potential pharmacological activities. However, the hepatoprotective effects and mechanisms of Morchella esculenta polysaccharide against nonalcoholic fatty liver disease (NAFLD) remain unknown. A high-fat diet (HFD) fed C57BL/6 J mice for 8 weeks was employed to establish NAFLD with simple steatosis, methionine choline deficiency (MCD) diet for 4 weeks induced hepatic steatohepatitis and fibrosis.
View Article and Find Full Text PDFMalatya apricot gum: A source of natural gum and its physicochemical, functional and antioxidant properties.
Int J Biol Macromol
January 2025
Department of Food Physics, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran. Electronic address:
Gums are commonly used in the food industry for their functional properties. However, the growing demand for sustainable and alternative sources has drawn attention to the need for identifying and characterizing non-conventional gum sources with comparable or enhanced features. This study aimed to investigate the exudate gum from apricot trees (Prunus armeniaca) in Malatya as a potential alternative.
View Article and Find Full Text PDFMuscle imaging in facioscapulohumeral muscular dystrophy research: A scoping review and expert recommendations.
Neuromuscul Disord
January 2025
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Clinical trial readiness is an important topic in the field of facioscapulohumeral muscular dystrophy (FSHD). As FSHD is a slowly progressive and clinically heterogeneous disease, imaging biomarkers have been proposed to complement clinical outcome measures. Muscle magnetic resonance imaging (MRI), ultrasound and dual energy X-ray absorptiometry (DEXA) have been used to measure disease severity, activity and progression.
View Article and Find Full Text PDFBone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization.
Cardiovasc Diabetol
January 2025
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, 100029, Beijing, China.
Introduction: Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies. However, their utility in treating diabetes-associated atherosclerosis remains largely unexplored. Here, we aimed to characterize BMSC-EV-mediated regulation of autophagy and macrophage polarization.
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