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Anti-arthritic Effects of Undifferentiated and Chondrogenic Differentiated MSCs in MIA-induced Osteoarthritis in Wistar Rats: Involvement of Oxidative Stress and Immune Modulation.
Curr Stem Cell Res Ther
January 2025
Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.
Introduction: Osteoarthritis (OA) is a degenerative joint disease that can affect the many tissues of the joint. There are no officially recognized disease-modifying therapies for clinical use at this time probably due to a lack of complete comprehension of the pathogenesis of the disease. In recent years, emerging regenerative therapy and treatments with stem cells both undifferentiated and differentiated cells have gained much attention as they can efficiently promote tissue repair and regeneration.
View Article and Find Full Text PDFThe Ability of Indigenous Plants in Alleviating Rheumatoid Arthritis: A Comprehensive Review.
Curr Rheumatol Rev
October 2024
Lovely Professional University. Phagwara, Punjab, India.
Article Synopsis
- Rheumatoid Arthritis (RA) is a chronic autoimmune disease mainly affecting individuals aged 30-50, characterized by symptoms like morning stiffness, joint pain, and fatigue.
- Various risk factors for RA include hormonal, genetic, and environmental influences, as well as lifestyle choices like smoking and diet.
- The review emphasizes the therapeutic potential of 17 native plant species with anti-arthritic properties, while also highlighting the need for more thorough research to confirm their efficacy and safety for RA treatment.
Targeted non-invasive Metformin-Curcumin co-loaded nanohyaluosomes halt osteoarthritis progression and improve articular cartilage structure: A preclinical study.
Int J Pharm
December 2024
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt. Electronic address:
Osteoarthritis (OA) is a degenerative disease that affects the quality of life in elderly and young populations. Current therapies using corticosteroids and non-steroidal anti-inflammatory drugs via parenteral or oral routes show limited ability to retard progression of the disease and achieve long term effectiveness and safety. Herein, the potential of MT-Cur combinatorial nano-formulations in OA management was explored for the first time.
View Article and Find Full Text PDFThe immunomodulatory enzyme IDO2 is an essential mediator of autoantibody production and joint inflammation in preclinical models of autoimmune arthritis. Although originally identified as a tryptophan-catabolizing enzyme, we recently discovered a previously unknown nonenzymatic pathway is essential for the proarthritic function of IDO2. We subsequently identified Runx1 (Runt-related transcription factor 1) as a potential component of the nonenzymatic pathway IDO2 uses to drive arthritis.
View Article and Find Full Text PDFFumaric acid per se and in combination with methotrexate arrests inflammation via moderating inflammatory and oxidative stress biomarkers in arthritic rats.
Immunopharmacol Immunotoxicol
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- Fumaric acid is a special substance found in fruits and vegetables that may help reduce inflammation and arthritis symptoms in rats.
- In the study, rats with arthritis were given fumaric acid and it helped lessen swelling and improve health markers in their bodies.
- The results showed that fumaric acid worked well, especially when combined with another medicine called methotrexate, but more research is needed before it can be used as a treatment for humans.
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