We developed a model by which the transvascular removal of unnecessary substances in brain edema fluid could be measured quantitatively and chronologically. Brain stab wounds were produced in Wistar rats by insertion of paired microdialysis probes in the unilateral caudatoputamen. Homovanillic acid (HVA) was administered by microdialysis from one probe, and the HVA clearance was measured by HPLC analysis of perfusate from the other probe. Using this model, we evaluated the site of removal and whether the removal processes were affected by anesthesia or an elevated plasma concentration of the substance. As a result, 1) Probenecid did not change HVA clearance although this inhibits HVA removal via subarachnoid vessels. Therefore, HVA removal in this model was considered mainly due to intraparenchymal transvascular efflux. 2) There was no alteration in HVA removal induced by anesthesia or intravenous HVA injection. Consequently, this efflux mechanism seems to be a rather stable protective process, and seems to play a considerable role in brain microenvironmental homeostasis.
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Subtalar arthroereisis for simultaneous treatment of flexible pes planus during surgical correction of hallux valgus.
Eur J Med Res
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National Center for Orthopaedics, Shanghai Sixth People's Hospital, 600 Yishan Road, Xuhui District, Shanghai, 200233, China.
Background: Scarf osteotomy is a well-established procedure for hallux valgus, yet recurrence rates range from 3.6% to 10%. Pes planus, which often coexisting with hallux valgus, is a risk factor for recurrence.
View Article and Find Full Text PDFBackground: There is a high correlation between hallux valgus and pes planus deformity. We sought to evaluate the outcomes of simultaneous Scarf osteotomy and extraosseous talotarsal stabilization (EOTTS) for correcting adult hallux valgus with flexible pes planus deformity.
Materials And Methods: This retrospective study enrolled patients who had hallux valgus deformity with flexible pes planus and underwent combined Scarf osteotomy and EOTTS from January 2018 to October 2021.
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View Article and Find Full Text PDFRigid iatrogenic hallux varus: a decades' worth experience with arthrodesis of the metatarsophalangeal joint.
Int Orthop
November 2024
Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università degli studi di Genova - DISC, Viale Benedetto XV 6, 16132, Genova, GE, Italy.
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Service de Chirurgie Orthopédique et Traumatologique, Hôpital Trousseau, CHRU de Tours, Avenue de la République, 37170 Chambray-lès-Tours, France; Centre de la Cheville et du Pied, Clinique Saint Léonard, 49800 Trélazé, France.
Article Synopsis
- - The modified Lapidus arthrodesis is an effective surgical technique for treating moderate to severe hallux valgus deformities, focusing on first tarsometatarsal joint hypermobility and enabling immediate weight-bearing post-surgery.
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- - Significant improvements in foot alignment were noted, with reductions in hallux valgus angle and intermetatarsal angle, indicating that this surgical method, when performed with a plantar plate and compression screw, is both reliable and beneficial for patients.
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