AI Article Synopsis
- Treatment with allyestrenol during pregnancy increased enzyme activity in female offspring but not in males.
- Adult males and females exposed to allyestrenol as embryos showed higher enzyme activity compared to those only treated with an anticonceptive steroid.
- Alcohol treatment in adulthood did not affect the results of embryonic allyestrenol exposure, and differences observed in the second generation were minimal.
Article Abstract
Treatment of pregnant rats with allyestrenol on the 15th and 19th days of pregnancy induced the activity of enzyme system of adult offspring in females while it did not influence it in males. The steroid anticoncipient treatment of adults decreased the activity of some enzymes of the PSMO. The adulthood anticoncipient steroid treatment of rats which encountered allylestrenol in their fetal age compared to the only anticoncipient steroid treated group produces an increased activity of the majority of the tested parameters both in females and males. The effect of the adulthood alcohol treatment was not influenced by the embryonic treatment with allylestrenol. Differences in the second generation are non-significant.
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