Results of the study evidence that in the early period of acute experimental pancreatitis (AEP)--from 10 minutes to 2 hours--changes in acino-capillary complex consist in compensatory-adaptive reaction and are related to metabolic disorders. Abortive interstitial oedema disappears in 20-30-minutes, dilated lymphatic vessels being visible macroscopically. Further progress of oedema with consequent focal haemorrhagic pancreonecrosis is possible in case of insufficient lymphatic drainage. The latter may be due both to destruction of lymphatic endotheliocytes and barrage of lymphatic ways with agglutinates. This indicates primacy of enzymatic alteration of pancreatocytes and secondary nature of vascular changes as well as necessity of early intensive care aimed at correction of lympho- and haemocirculation.
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