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Controversial Roles of Autophagy in Adenomyosis and Its Implications for Fertility Outcomes-A Systematic Review.
J Clin Med
December 2024
Laboratory of Tumor and Development Biology, Giga-Cancer, University of Liège, 4000 Liege, Belgium.
Adenomyosis is a benign condition where ectopic endometrial glandular tissue is found within the uterine myometrium. Its impact on women's reproductive outcomes is substantial, primarily due to defective decidualization, impaired endometrial receptivity, and implantation failure. The exact pathogenesis of the disease remains unclear, and the role of autophagy in adenomyosis and its associated infertility is not well understood.
View Article and Find Full Text PDFPeripheral myelin: From development to maintenance.
J Neurochem
January 2025
Laboratory of Nervous System Disorders and Therapies, GIGA Institute, University of Liège, Liège, Belgium.
Peripheral myelin is synthesized by glial cells called Schwann cells (SCs). SC development and differentiation must be tightly regulated to avoid any pathological consequence affecting peripheral nerve function. Neuropathic symptoms can arise from developmental issues in SCs, as well as in adult life through processes affecting mature SCs.
View Article and Find Full Text PDFIntratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity.
Nat Commun
December 2024
Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium.
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxicities. Here, we develop and employ lipid-based nanoparticles (LNPs) to intratumorally deliver an mRNA mixture encoding the cytokines interleukin (IL)-21 and IL-7 and the immunostimulatory molecule 4-1BB ligand (Triplet LNP). IL-21 synergy with IL-7 and 4-1BBL leads to a profound increase in the frequency of tumor-infiltrating CD8 T cells and their capacity to produce granzyme B and IFN-γ, leading to tumor eradication and the development of long-term immunological memory.
View Article and Find Full Text PDFApomorphine for prolonged disorders of consciousness: a multimodal open-label study.
EClinicalMedicine
December 2024
Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium.
Background: Apomorphine is a dopaminergic candidate therapy to improve recovery in patients with prolonged disorders of consciousness (PDoC). Behavioural improvements were previously described in non-controlled case series, but its efficacy and neural mechanisms remain largely unknown. This open-label controlled study using multimodal outcome measures investigates the action of apomorphine in severely brain-injured patients.
View Article and Find Full Text PDFThe Multiple Dimensions of Familiarity: From Representations to Phenomenology.
Wiley Interdiscip Rev Cogn Sci
December 2024
GIGA Research, CRC Human Imaging, University of Liège, Liege, Belgium.
This article focuses on familiarity, the form of memory allowing humans to recognize stimuli that have been encountered before. We aim to emphasize its complex nature which includes representational and phenomenological dimensions. The former implies that its neural correlates depend on the type and complexity of the cue stimulus, as different classes of stimuli are represented in distributed ventral visual and medial temporal regions.
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