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Assessing the efficacy of metacognitive therapy as monotherapy or adjunctive treatment in patient suffering from major depression and dysthimia: A comprehensive review of clinical trials.
J Affect Disord
February 2025
Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, Italy. Electronic address:
Background: Depression is one of the most widespread diseases worldwide, with the highest rates of disability. Considering its chronic course, over the years several treatment options have been developed and validated, however still with high relapse rates. Therefore, in recent years, the so-called third wave psychotherapies have been developed for the treatment of psychiatric disorders.
View Article and Find Full Text PDFDemographic characteristics and comorbidities of patients with narcolepsy: a propensity-matched cohort study.
Sleep Adv
September 2024
Avadel Pharmaceuticals, Chesterfield, MO, USA.
Article Synopsis
- This study examined the demographics and comorbidities of patients with narcolepsy by analyzing electronic health records (EHR) using natural language processing (NLP) algorithms, marking a novel approach in this area.
- Researchers identified 2,057 narcolepsy patients at the Mayo Clinic from 2000 to 2020 and compared them with a matched control group, focusing on various comorbid conditions.
- The findings revealed that narcolepsy patients have higher instances of sleep disorders, mood disorders, and pain-related conditions, indicating that their challenges extend beyond just narcolepsy symptoms.
Childhood Trauma Questionnaire-based child maltreatment profiles to predict efficacy of the Cognitive Behavioral Analysis System of Psychotherapy versus non-specific psychotherapy in adults with early-onset chronic depression: cluster analysis of data from a randomised controlled trial.
Lancet Psychiatry
September 2024
Department of Psychiatry and Psychotherapy, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany; DZPG (German Center for Mental Health), Partner Site Munich-Augsburg, Munich, Germany. Electronic address:
Article Synopsis
- Child maltreatment is a major risk factor for mental and physical health issues, and certain therapeutic approaches, like CBASP, aim to address these risks specifically for conditions like chronic depression.
- This study analyzed data from a previous clinical trial involving patients with early-onset chronic depression to understand how patterns of child maltreatment might predict therapy outcomes between CBASP and supportive psychotherapy.
- Using a clustering approach from childhood trauma data, the research sought to determine if different maltreatment histories could lead to varying levels of improvement in depression symptoms over a two-year period post-treatment.
Correlates of disability among primary care patients with common mental disorders and chronic medical conditions- a cross-sectional study from rural South India.
Soc Psychiatry Psychiatr Epidemiol
July 2024
Division of Mental Health and Neurosciences, St. John's Research Institute, Sarjapur Road, Bengaluru, Karnataka, 560034, India.
Purpose: We examined the correlates of disability among people with non-communicable diseases (NCDs) and comorbid common mental disorders (CMDs) from rural India.
Methods: The sample comprised 2,486 participants enrolled in a cluster randomized trial (cRCT), Healthier OPtions through Empowerment (HOPE). Participants were 30 years or older, with a diagnosis of major depressive disorder, dysthymia, generalized anxiety disorder, and/or panic disorder on the MINI-International Neuropsychiatric Interview, with hypertension, diabetes, dsylipidemia and/ or ischemic heart disease.
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