A case is described of gentamicin induced thrombocytopenic diathesis in 65-year old woman. Pathogenesis of drug induced thrombocytopenia is briefly discussed as well as outlines of treatment.
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The intestinal flora: The key to unraveling heterogeneity in immune thrombocytopenia?
Blood Rev
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Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands. Electronic address:
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by enhanced platelet destruction and impaired platelet production, due to a loss of immune tolerance that leads to targeting of platelets and megakaryocytes by glycoprotein-autoantibodies and/or cytotoxic T cells. There is a high degree of heterogeneity in ITP patients signified by unpredictable disease trajectories and treatment responses. Initial studies in humans have identified intestinal microbiota perturbance in ITP.
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View Article and Find Full Text PDFGenetic predisposition to vaccine-induced immune thrombotic thrombocytopenia.
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Article Synopsis
- Immune thrombocytopenic purpura (ITP) is an autoimmune disorder possibly influenced by gut microbiota and inflammatory cytokines, but the relationships are not fully understood.
- A study utilized Mendelian randomization to explore the causal links between gut microbiota and ITP, finding 11 microbiota species that increase ITP risk and 12 that decrease it.
- The research identified CXCL10, CXCL5, and VEGF-A as key inflammatory cytokines mediating the effects of certain gut microbiota on ITP, suggesting new potential targets for treatment and prevention.
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