We conducted a double-blind randomized prospective study to evaluate the efficacy of topical timolol alone and topical timolol and atropine combined in cases of operated failed retinal detachment surgery cases in which no apparent open break explained the surgical failure. In both groups with and without proliferative vitreoretinopathy no statistically significant difference in retinal reattachment was found.
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http://dx.doi.org/10.1159/000310489 | DOI Listing |
Oestrogen and progesterone fluctuate cyclically in women throughout their adult lives. Although these hormones cross the blood-retinal barrier and bind to intraocular receptors, their effects remain unclear. We present the first review to date on associations between posterior pole structures-specifically the macula, choroid, and optic disc-and both the menstrual cycle and post-menopausal period, utilising multimodal imaging techniques in healthy adult non-pregnant women.
View Article and Find Full Text PDFRetinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which a loss of retinal vasculature leads to ischemia followed by a compensatory neovascularization response. In mice, this is modeled using oxygen-induced retinopathy (OIR), whereby neonatal animals are transiently housed under hyperoxic conditions that result in central retina vessel regression and subsequent neovascularization. Using endothelial cell (EC)-specific gene deletion, we found that loss of two ETS-family transcription factors, ERG and FLI1, led to regression of OIR-induced neovascular vessels but failed to improve visual function, suggesting that relevant retinal damage occurs prior to and independently of neovascularization.
View Article and Find Full Text PDFNeural Netw
December 2024
School of Cyberspace, Hangzhou Dianzi University, Hangzhou, 310018, China; Suzhou Research Institute of Shandong University, Suzhou, 215123, China. Electronic address:
Domain Generalization-based Medical Image Segmentation (DGMIS) aims to enhance the robustness of segmentation models on unseen target domains by learning from fully annotated data across multiple source domains. Despite the progress made by traditional DGMIS methods, they still face several challenges. First, most DGMIS approaches rely on static models to perform inference on unseen target domains, lacking the ability to dynamically adapt to samples from different target domains.
View Article and Find Full Text PDFIndian J Ophthalmol
January 2025
Vitreoretinal Services, Shroff Eye Centre, New Delhi, India.
Purpose: The management of idiopathic macular holes (iMH) has evolved over time with various modifications in surgical approach. The study aimed to survey the surgeons' preferences in the management of iMH in current times.
Design: Cross-sectional descriptive survey.
Objective: To describe the anatomical and functional outcome of autologous internal limiting membrane (ILM) transplant with 27-gauge plus (27G+) three ports pars plana vitrectomy (PPV) in failed and recurrent full-thickness macular holes (MH) in a spectrum of pathologies.
Study Design: Observational cohort study Methods: Seven eyes of seven patients who had failed or recurrent MH were included from January 2017 to January 2022. A single vitreoretinal surgeon performed all surgeries using a 27G+ PPV system in a tertiary care hospital.
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