A 3 years old patient receiving chemotherapy for acute-lymphoblastic leukemia according to the ALL-BFM 90-treatment protocol developed thrombosis of the vena axillaris. Without removing the central venous catheter located at the site of thrombosis it was possible to lyse the thrombus by the systemic application of recombinant human tissue-type plasminogen activator (rt-PA). The method is recommended for the treatment of thrombotic occlusions in children.
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