The article deals with the experience in the treatment of 220 children with generalized forms of purulent peritonitis of various origin (appendicular, posttraumatic, consequence of destructive pancreatitis and other inflammatory processes in the abdominal cavity). A scheme of therapeutic measures which were applied for the control of infection and endotoxicosis is given. They include homeostasis by means of extracorporeal detoxification, differentiated immunocorrection, quantum therapy, and other modern methods of treatment. Mortality among the patients was 5.9%, while before the introduction of the described methods into practice it was 13.2%.
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Chem Commun (Camb)
January 2025
Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Singapore 627833, Republic of Singapore.
Polymeric materials are ubiquitous in modern life. Similar to many other technological applications, polymer materials are essential in advancing the green hydrogen economy, offering solutions for hydrogen production, storage, transport, and utilization. In production, polymeric proton exchange membranes in water electrolysers enable efficient green hydrogen generation using renewable energy.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Center for Violence and Injury Prevention, Brown School at Washington University, St. Louis, MO 63130.
Violence against women and girls (VAWG) is a leading cause of mortality and morbidity worldwide, linked to numerous health, economic, and human rights outcomes. Target 5.2 of the Sustainable Development Goals calls for elimination of all forms of VAWG; however, progress toward achieving this goal has been inadequate.
View Article and Find Full Text PDFInt J Hematol
January 2025
Department of Hematology, The 920th Hospital of Joint Logistics Support Force, No.212, Da Guan Road, Xishan District, Kunming, 650100, Yunnan, China.
Background: The treatment of relapsed/refractory T cell acute lymphoblastic leukemia (R/R T-ALL) is a significant challenge in hematologic oncology, and no standard salvage treatment plan exists. Both Chinese and international clinical guidelines recommend combination chemotherapy including venetoclax.
Methods: Efficacy and safety of venetoclax, azacitidine, homoharringtonine, cytarabine, and aclarubicin (VA-HAA) combination therapy were retrospectively analyzed in 3 patients with R/R T-ALL at the Department of Hematology, 920th Hospital of the Joint Logistics Support Force, Chinese People's Liberation Army.
Expert Rev Med Devices
January 2025
Italian Society of Hospital Pharmacy (SIFO), SIFO Secretariat of the Lombardy Region, Milan, Italy.
Introduction: Digital therapeutics (DTx) are an emerging phenomenon within the scientific landscape which is attracting considerable international interest. This review aimed to provide an overview of the definition and classification of DTx, focusing on the contribution that DTx may provide in the treatment of a lot of diseases, compared with pharmacological treatments and highlighting it strengthens and weaknesses into the European regulatory landscape.
Areas Covered: They are software-generated therapeutic interventions directly to patients useful to prevent, manage or treat diseases.
J Org Chem
January 2025
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Sciences, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China.
-Difluorohomoallyl amines, an important class of -difluoroalkenes, are prevalent moieties in many bioactive compounds. However, limited methods are suitable for the synthesis of this type of compound containing secondary amines. Here, we display a photocatalytic multicomponent protocol for the synthesis of -difluoroalkenes containing secondary amines, which makes use of readily available materials: arylamines, alkyl aldehydes, and α-trifluoromethyl alkenes.
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