Electromagnetic flowmetry and analogue computers were used to evaluate changes in great venous and arterial blood flow and resistance alterations in the vessels after nifedipine and verapamil in experiments with 12 anesthesized cats. The agents were demonstrated to increase cardiac output due to lower afterload and venous return, to redistribute cardiac output towards greater brain blood supply. The latter was caused by a more marked decrease in vascular resistance in the brachiocephalic arterial tree than in the descending thoracic artery. Blood flow changes in the great arteries determined those in the vena cava superior and inferior.
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Int J Cardiol Cardiovasc Risk Prev
March 2025
Department of Public and Occupational Health, Amsterdam Public health Research Institute, Amsterdam university Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
J Am Heart Assoc
October 2024
Regenerative Medicine Institute, School of Medicine University of Galway Galway Ireland.
Kidney Res Clin Pract
November 2024
School of Nursing, Miyagi University, Miyagi, Japan.
Elderly patients are prone to develop hyper- or hypokalemia, since they are susceptible to drugs or diets that affect the urinary or fecal potassium (K+) excretion. In aging mouse kidneys, in addition to glomerulosclerosis, proximal tubular atrophy, and atherosclerosis in renal arterioles, there was diffuse tubulointerstitial fibrosis with a number of inflammatory leukocytes infiltrating into the cortical interstitium. Since these pathological features greatly influence renal K+ handling, slowing the progression of kidney aging would fundamentally reduce the risk of developing hyper- or hypokalemia.
View Article and Find Full Text PDFParasitol Res
March 2024
Centro de Estudios Biomédicos y Veterinarios, Instituto de Estudios Científicos y Tecnológicos (IDECYT), Universidad Nacional Experimental Simón Rodríguez, Caracas, Venezuela.
The hemoparasite Trypanosoma equiperdum belongs to the Trypanozoon subgenus and includes several species that are pathogenic to animals and humans in tropical and subtropical areas across the world. As with all eukaryotic organisms, Ca is essential for these parasites to perform cellular processes thus ensuring their survival across their life cycle. Despite the established paradigm to study proteins related to Ca homeostasis as potential drug targets, so far little is known about Ca entry into trypanosomes.
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