In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV-1. T lymphocytes from pigtailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV-1 isolates were unable to productively infect pigtailed macaque cells. Inoculation of autologous, HIV-1 expressing cells led to establishment of persistent infection in pigtailed macaques as evidenced by recovery of infectious virus and development of virus-specific antibody responses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0684.1994.tb00117.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineering vaginal film platform for mucoadhesion and sustained drug release for HIV-1 prevention.
J Control Release
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, Pittsburgh, PA, USA; Department of Obstetrics, Gynecology & Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
User adherence contributes to the effectiveness of topical pre-exposure prophylactic products designed to protect against human immunodeficiency virus type 1 (HIV-1) infection. Long-acting approaches that do not require daily or coitally-dependent use could potentially improve user adherence. This study aims to develop a long-acting vaginal film to deliver an integrase inhibitor, MK-2048, for prevention of HIV-1 infection.
View Article and Find Full Text PDFAn Assessment of the Diversity and Seasonal Dynamics of Small- and Medium-Sized Mammals in Pittachhara Forest, Bangladesh, Using a Camera Trap Survey.
Animals (Basel)
December 2024
Laboratory of Wildlife Resources, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
The Chattogram Hill Tracts (CHTs) in Bangladesh have a rich biodiversity, hosting a wide range of wild mammal species, underscoring the importance of systematic monitoring focused on conservation efforts. This study aims to assess the diversity and abundance of small- and medium-sized wild mammal species in Pittachhara Forest in the CHTs. A comprehensive wildlife monitoring survey was conducted in this forest using strategically placed camera traps to identify the wild species diversity, and we evaluated the activity patterns and seasonal variations for the period of February 2023 to August 2024.
View Article and Find Full Text PDFSize and canopy characteristics of community reserves determine primate occupancy in the state of Meghalaya, India, and implications for its conservation.
Folia Primatol (Basel)
December 2024
119671Sálim Ali Centre for Ornithology and Natural History, Anaikatty Post, Coimbatore, 641 108, Tamil Nadu, India.
Globally, the effective protected area network is one of the last resorts for conserving biodiversity. The nature of protected areas depends on the land ownership of the respective countries including India. The landholding in the northeastern states of India remains with native people, thus, 'Community Reserve' (CR) was introduced in 2003.
View Article and Find Full Text PDFComparative lifespan and healthspan of nonhuman primate species common to biomedical research.
Geroscience
November 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed in 12 translational aging models: baboon, bonnet macaque, chimpanzee, common marmoset, coppery titi monkey, cotton-top tamarin, cynomolgus macaque, Japanese macaque, pigtail macaque, rhesus macaque, squirrel monkey, and vervet/African green. After employing strict inclusion criteria, primary results are based on 12,269 NHPs that survived to adulthood and died of natural/health-related causes.
View Article and Find Full Text PDFIFI27 inhibits HIV-1 replication by degrading Gag protein through the ubiquitin-proteasome pathway.
J Virol
November 2024
State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Article Synopsis
- Type I interferon (IFN-I) and its gene IFI27 are crucial in controlling HIV-1 infection by effectively suppressing viral replication and degrading its proteins, p24 and p55.
- The study found that the IFI27 variant from northern pig-tailed macaques (NPM-IFI27) is particularly effective against HIV-1, utilizing the ubiquitin-proteasome pathway to target and degrade viral proteins.
- These results highlight the potential of NPM-IFI27 as a promising candidate for new antiviral therapies against HIV-1, emphasizing the need for ongoing research in host antiviral agents.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!