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Africa, with 18.3% of the world's population, faces a significant research output gap, contributing only 2% of global research despite bearing a substantial disease burden. This discrepancy is partly due to inadequate research infrastructure, limited funding, and a shortage of physician-scientists.
View Article and Find Full Text PDFMibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics.
Nucleic Acids Res
July 2024
Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.
Quantifying microbiome species and composition from metagenomic assays is often challenging due to its time-consuming nature and computational complexity. In Bioinformatics, k-mer-based approaches were long established to expedite the analysis of large sequencing data and are now widely used to annotate metagenomic data. We make use of k-mer counting techniques for efficient and accurate compositional analysis of microbiota from whole metagenome sequencing.
View Article and Find Full Text PDFThe creation of an adaptable informed consent form for research purposes to overcome national and institutional bottlenecks in ethics review: experience from rare disease registries.
Front Med (Lausanne)
April 2024
European Joint Programme on Rare Diseases Coordination, INSERM, Paris, France.
Background: The lack of harmonization of evaluation criteria by Ethics Committees in the European Union (EU) has led to inconsistent ethics reviews received by research sites participating in multicenter non-interventional studies. The European General Data Protection Regulation (GDPR) appears to be implemented at national level with a substantial degree of variance in interpretation. The European Reference Networks (ERNs) were struggling in setting an Informed Consent Form (ICF) for registries, allowing reuse of data for research purposes.
View Article and Find Full Text PDFThe Long COVID Symptoms and Severity Score: Development, Validation, and Application.
Value Health
August 2024
Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address:
Objectives: The primary focus of this research is the proposition of a methodological framework for the clinical application of the long COVID symptoms and severity score (LC-SSS). This tool is not just a self-reported assessment instrument developed and validated but serves as a standardized, quantifiable means to monitor the diverse and persistent symptoms frequently observed in individuals with long COVID.
Methods: A 3-stage process was used to develop, validate, and establish scoring standards for the LC-SSS.
Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index.
Clin Transl Med
February 2024
Department of Orthopaedic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, P. R. China.
Background: Osteosarcoma (OSA) presents a clinical challenge and has a low 5-year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to stratify high-risk OSA patients and guide treatment.
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