AI Article Synopsis
- Glutathione levels decreased and lipid peroxide levels increased in liver tissues 6 hours after paracetamol treatment (500 mg/kg).
- Cytosolic glutathione S-transferase (GST) activity declined, while glutathione peroxidase (GSH-Px) activity stayed the same.
- In liver microsomes, lower lipid peroxide levels coincided with increased GST and GSH-Px activity, suggesting these enzymes help protect against lipid peroxidation.
Article Abstract
Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg-1 i.p.). Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities. In this way, these glutathione-related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.
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| http://dx.doi.org/10.1002/jat.2550140410 | DOI Listing |
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