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Patient-derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas.
Clin Cancer Res
January 2025
ACTREC, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.
Purpose: Identifying therapeutic targets for Signet Ring Cell Carcinoma (SRCC) of the colon and rectum is a clinical challenge due to the lack of Patient-Derived Organoids (PDO) or Xenografts (PDX). We present a robust method to establish PDO and PDX models to answer address this unmet need. We demonstrate that these models identify novel therapeutic strategies targeting therapy resistance and peritoneal metastasis.
View Article and Find Full Text PDFDecay of self-incompatibility within a lifespan in Physalis acutifolia (Solanaceae).
Plant Reprod
January 2025
Department of Ecology and Evolutionary Biology, University of Colorado, 1900 Pleasant Street, Boulder, CO, 80309, USA.
Self-incompatibility decays with age in plants of Physalis acutifolia, and plants that have transitioned to selfing produce fewer seeds but with comparable viability. Self-compatibility in this system is closely related to flower size, which is in turn dependent on the direction of the cross, suggesting parental effects on both morphology and compatibility. The sharpleaf groundcherry, Physalis acutifolia, is polymorphic for self-compatibility, with naturally occurring self-incompatible (SI) and self-compatible (SC) populations.
View Article and Find Full Text PDFObjectives: This study aims to define criteria for robotic reconstructive and functional urology credentialing using expert consensus. A recent narrative review identified a lack of standardised minimal requirements for performing robotic-assisted surgery procedures. The substantial variability or absence of a standardised curriculum and credentialing process within a highly specialised surgical field is often insufficient to guarantee surgeon proficiency and could potentially jeopardise patient safety.
View Article and Find Full Text PDFImpact of different pathogen classes on the serum -glycome in septic shock.
BBA Adv
January 2025
School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia.
The morbidity and mortality of sepsis remain high. Clinicians lack effective markers to rapidly diagnose sepsis and identify the underlying pathogen infection particularly for patients with candidaemia or cases of culture-negative sepsis where culture-based diagnostics are inadequate. In our search for new lines of potential sepsis biomarkers, we here explore the impact of various classes of infectious agents on the serum -glycome in a septic shock cohort.
View Article and Find Full Text PDFComputed tomographic features of clinically suspected rhinitis in domestic rabbits (Oryctolagus cuniculus).
Vet Rec
January 2025
Department of Small Animals Diagnostic Imaging, École Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.
Background: The aim of this study was to characterise the computed tomographic (CT) findings in domestic rabbits with clinically suspected rhinitis and compare them with CT findings in rabbits without clinical signs of rhinitis.
Methods: CT images of rabbits that underwent a CT of the head were retrospectively reviewed and any CT abnormalities were described. Statistical analysis was performed to detect any association between the CT findings and clinical signs of rhinitis, and also to assess if there was any association between rhinitis and otitis media, otitis externa or dental disease.
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