Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1042/bst022223s | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
Med Oncol
March 2025
School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
This study unveils PKM2 as a master metabolic coordinator in triple-negative breast cancer (TNBC), governing the glycolysis-lipolysis balance through the AMPK/KLF4/ACADVL axis. We demonstrate stage-specific PKM2 upregulation in TNBC, with CRISPR/Cas9 knockout inducing dual metabolic reprogramming-suppressed glycolysis and activated lipid catabolism. Mechanistically, PKM2 ablation triggers AMPK-dependent nuclear translocation of KLF4, which directly activates ACADVL (mitochondrial β-oxidation rate-limiting enzyme), explaining lipid droplet depletion.
View Article and Find Full Text PDFDTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma.
Drug Resist Updat
February 2025
Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510080, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; South China University of Technology School of Medicine, Guangzhou, Guangdong 510006, China. Electronic address:
Aims: Emerging resistance to Lenvatinib, which is used as a first-line agent for the treatment of advanced hepatocellular carcinoma (HCC), is still a concern. The aim of this study was to determine core factors of Lenvatinib resistance (LR) and their underlying molecular mechanisms.
Methods: CRISPR screening in HCC cells was conducted, which identified E3 ubiquitin ligase deltex 2 (DTX2) as a core LR-related gene.
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
Free Radic Biol Med
March 2025
National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning Province, 116044, China; School of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian, Liaoning Province, 116044, China. Electronic address:
Background: Parkinson's disease (PD) is the most common neurodegenerative movement disorder with uncleared mechanisms. Short-chain enoyl-CoA hydratase 1 (ECHS1) is a mitochondrial enzyme critical for the β-oxidation of fatty acids and ATP production. This study aims to explore the roles of ECHS1 in PD by using rotenone-induced experimental PD models.
View Article and Find Full Text PDFIntegrative Omics reveals changes in the cellular landscape of peroxisome-deficient yeast cells.
Microb Cell
February 2025
Theodor-Boveri-Institute, Biochemistry II, Faculty of Chemistry and Pharmacy, University of Würzburg 97074 Würzburg Germany.
Peroxisomes are organelles that are crucial for cellular metabolism, but they also play important roles in non-metabolic processes such as signalling, stress response or antiviral defense. To uncover the consequences of peroxisome deficiency, we compared wild-type with cells, which lack peroxisomes, employing quantitative proteomics and transcriptomics technologies. Cells were grown on acetate, a carbon source that requires peroxisomal enzymes of the glyoxylate cycle to generate energy and essential carbohydrates, and that does not repress the expression of peroxisomal genes.
View Article and Find Full Text PDFLive yeast (Saccharomyces cerevisiae) improves growth performance and liver metabolic status of lactating Hu sheep.
J Dairy Sci
February 2025
Ministry of Education Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China 210095. Electronic address:
Yeast, a natural starter culture, is widely used to improve digestion function in ruminants. However, whether yeast affects the physiological state of the liver in ruminants is currently unknown. The aim of this study was to investigate the effects of yeast on liver metabolic status and physiological functions of Hu sheep during lactation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!